Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success

Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self‐renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their c...

Descripción completa

Detalles Bibliográficos
Autores principales: Desai, Amar, Yan, Yan, Gerson, Stanton L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Translational Research Articles and Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312440/
https://www.ncbi.nlm.nih.gov/pubmed/30328686
http://dx.doi.org/10.1002/sctm.18-0123
_version_ 1783383779100852224
author Desai, Amar
Yan, Yan
Gerson, Stanton L.
author_facet Desai, Amar
Yan, Yan
Gerson, Stanton L.
author_sort Desai, Amar
collection PubMed
description Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self‐renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs within a heterogeneous tumor, and here we summarize ongoing preclinical and clinical efforts to therapeutically target these cells and improve patient outcomes. Stem Cells Translational Medicine 2019;8:75–81
format Online
Article
Text
id pubmed-6312440
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-63124402019-01-07 Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success Desai, Amar Yan, Yan Gerson, Stanton L. Stem Cells Transl Med Translational Research Articles and Reviews Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self‐renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs within a heterogeneous tumor, and here we summarize ongoing preclinical and clinical efforts to therapeutically target these cells and improve patient outcomes. Stem Cells Translational Medicine 2019;8:75–81 John Wiley & Sons, Inc. 2018-10-17 /pmc/articles/PMC6312440/ /pubmed/30328686 http://dx.doi.org/10.1002/sctm.18-0123 Text en © 2018 The Authors. stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Translational Research Articles and Reviews
Desai, Amar
Yan, Yan
Gerson, Stanton L.
Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success
title Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success
title_full Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success
title_fullStr Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success
title_full_unstemmed Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success
title_short Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success
title_sort concise reviews: cancer stem cell targeted therapies: toward clinical success
topic Translational Research Articles and Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312440/
https://www.ncbi.nlm.nih.gov/pubmed/30328686
http://dx.doi.org/10.1002/sctm.18-0123
work_keys_str_mv AT desaiamar concisereviewscancerstemcelltargetedtherapiestowardclinicalsuccess
AT yanyan concisereviewscancerstemcelltargetedtherapiestowardclinicalsuccess
AT gersonstantonl concisereviewscancerstemcelltargetedtherapiestowardclinicalsuccess

Ejemplares similares