Akt2 mediates glucocorticoid resistance in lymphoid malignancies through FoxO3a/Bim axis and serves as a direct target for resistance reversal

Glucocorticoids (GCs) are widely used drugs in the treatment of lymphoid malignancies; resistance of GCs in lymphocytes confers poor prognosis and the mechanisms are poorly understood. Here, we found T-acute lymphoblastic leukemia (T-ALL) cells acquire resistance to dexamethasone (DEX)-mediated kill...

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Detalles Bibliográficos
Autores principales: Xie, Mixue, Yang, Apeng, Ma, Jiexian, Wu, Min, Xu, Hongyue, Wu, Kefei, Jin, Youxin, Xie, Yanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312545/
https://www.ncbi.nlm.nih.gov/pubmed/30598523
http://dx.doi.org/10.1038/s41419-018-1043-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312545/
https://www.ncbi.nlm.nih.gov/pubmed/30598523
http://dx.doi.org/10.1038/s41419-018-1043-6

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