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Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair
In recent years, the study of metabolomics has begun to receive increasing international attention, especially as it pertains to medical research. This is due in part to the potential for discovery of new biomarkers in the metabolome and to a new understanding of the “exposome”, which refers to the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312607/ https://www.ncbi.nlm.nih.gov/pubmed/30662903 http://dx.doi.org/10.1155/2018/2815439 |
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author | Delplancke, Thibaut D. J. Wu, Yue Han, Ting-Li Joncer, Lingga R. Qi, Hongbo Tong, Chao Baker, Philip N. |
author_facet | Delplancke, Thibaut D. J. Wu, Yue Han, Ting-Li Joncer, Lingga R. Qi, Hongbo Tong, Chao Baker, Philip N. |
author_sort | Delplancke, Thibaut D. J. |
collection | PubMed |
description | In recent years, the study of metabolomics has begun to receive increasing international attention, especially as it pertains to medical research. This is due in part to the potential for discovery of new biomarkers in the metabolome and to a new understanding of the “exposome”, which refers to the endogenous and exogenous compounds that reflect external exposures. Consequently, metabolomics research into pregnancy-related issues has increased. Biomarkers discovered through metabolomics may shed some light on the etiology of certain pregnancy-related complications and their adverse effects on future maternal health and infant development and improve current clinical management. The discoveries and methods used in these studies will be compiled and summarized within the following paper. A further focus of this paper is the use of hair as a biological sample, which is gaining increasing attention across diverse fields due to its noninvasive sampling method and the metabolome stability. Its significance in exposome studies will be considered in this review, as well as the potential to associate exposures with adverse pregnancy outcomes. Currently, hair has been used in only two metabolomics studies relating to fetal growth restriction (FGR) and gestational diabetes mellitus (GDM). |
format | Online Article Text |
id | pubmed-6312607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63126072019-01-20 Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair Delplancke, Thibaut D. J. Wu, Yue Han, Ting-Li Joncer, Lingga R. Qi, Hongbo Tong, Chao Baker, Philip N. Biomed Res Int Review Article In recent years, the study of metabolomics has begun to receive increasing international attention, especially as it pertains to medical research. This is due in part to the potential for discovery of new biomarkers in the metabolome and to a new understanding of the “exposome”, which refers to the endogenous and exogenous compounds that reflect external exposures. Consequently, metabolomics research into pregnancy-related issues has increased. Biomarkers discovered through metabolomics may shed some light on the etiology of certain pregnancy-related complications and their adverse effects on future maternal health and infant development and improve current clinical management. The discoveries and methods used in these studies will be compiled and summarized within the following paper. A further focus of this paper is the use of hair as a biological sample, which is gaining increasing attention across diverse fields due to its noninvasive sampling method and the metabolome stability. Its significance in exposome studies will be considered in this review, as well as the potential to associate exposures with adverse pregnancy outcomes. Currently, hair has been used in only two metabolomics studies relating to fetal growth restriction (FGR) and gestational diabetes mellitus (GDM). Hindawi 2018-12-18 /pmc/articles/PMC6312607/ /pubmed/30662903 http://dx.doi.org/10.1155/2018/2815439 Text en Copyright © 2018 Thibaut D. J. Delplancke et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Delplancke, Thibaut D. J. Wu, Yue Han, Ting-Li Joncer, Lingga R. Qi, Hongbo Tong, Chao Baker, Philip N. Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair |
title | Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair |
title_full | Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair |
title_fullStr | Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair |
title_full_unstemmed | Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair |
title_short | Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair |
title_sort | metabolomics of pregnancy complications: emerging application of maternal hair |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312607/ https://www.ncbi.nlm.nih.gov/pubmed/30662903 http://dx.doi.org/10.1155/2018/2815439 |
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