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Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study

NM23 expression is closely associated with hepatocellular carcinoma (HCC) recurrence, but the hereditary factors influencing NM23 levels are unknown. Using public database, the diagnostic value of NM23 in HCC was investigated. A total of 424 hepatitis B virus- (HBV-) related HCC patients were enroll...

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Autores principales: Yang, Chengkun, Han, Chuangye, Wang, Xiangkun, Liao, Xiwen, Liu, Xiaoguang, Qin, Wei, Yu, Long, Zhu, Guangzhi, Su, Hao, Lu, Sicong, Chen, Zhiwei, Yu, Tingdong, Liu, Zhen, Huang, Ketuan, Liu, Zhengtao, Liang, Yu, Huang, Jianlu, Peng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312618/
https://www.ncbi.nlm.nih.gov/pubmed/30662464
http://dx.doi.org/10.1155/2018/6594169
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author Yang, Chengkun
Han, Chuangye
Wang, Xiangkun
Liao, Xiwen
Liu, Xiaoguang
Qin, Wei
Yu, Long
Zhu, Guangzhi
Su, Hao
Lu, Sicong
Chen, Zhiwei
Yu, Tingdong
Liu, Zhen
Huang, Ketuan
Liu, Zhengtao
Liang, Yu
Huang, Jianlu
Peng, Tao
author_facet Yang, Chengkun
Han, Chuangye
Wang, Xiangkun
Liao, Xiwen
Liu, Xiaoguang
Qin, Wei
Yu, Long
Zhu, Guangzhi
Su, Hao
Lu, Sicong
Chen, Zhiwei
Yu, Tingdong
Liu, Zhen
Huang, Ketuan
Liu, Zhengtao
Liang, Yu
Huang, Jianlu
Peng, Tao
author_sort Yang, Chengkun
collection PubMed
description NM23 expression is closely associated with hepatocellular carcinoma (HCC) recurrence, but the hereditary factors influencing NM23 levels are unknown. Using public database, the diagnostic value of NM23 in HCC was investigated. A total of 424 hepatitis B virus- (HBV-) related HCC patients were enrolled to perform a genome–wide association study for identifying candidate variants associated with NM23 expression level. Additionally, a logistic regression model, haplotypes, and survival analysis were performed in the subsequent analysis. We identified high NM23 expression levels that have a diagnostic accuracy in HCC tissues and had a poor recurrence-free survival in HBV-related HCC patients. Variants near Psoriasis susceptibility 1 candidate 1 (PSORS1C1) and StAR related lipid transdomain containing 3 (STARD3) are associated with NM23 expression. The PSORS1C1 haplotype TGCACA and the STARD3 haplotype GG have favorable cumulative effects on NM23 expression. Further, variants in PSORS1C1 were associated with either overall survival (rs556285588, rs3095301, and rs3131003) only or overall survival and recurrence-free survival (rs560052000 and rs541820233) both in HCC patients. Our findings suggested that variants at the PSORS1C1 and STARD3 loci play an important role in NM23 regulation. Moreover, variants in PSORS1C1 are potential biomarkers for the prediction of postoperative clinical outcomes in HBV-related HCC patients. Thus, variants in PSORS1C1 and STARD3 are associated with NM23 expression and clinical outcomes of HBV-related HCC patients, which may be regarded as potential biomarkers for this disease.
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spelling pubmed-63126182019-01-20 Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study Yang, Chengkun Han, Chuangye Wang, Xiangkun Liao, Xiwen Liu, Xiaoguang Qin, Wei Yu, Long Zhu, Guangzhi Su, Hao Lu, Sicong Chen, Zhiwei Yu, Tingdong Liu, Zhen Huang, Ketuan Liu, Zhengtao Liang, Yu Huang, Jianlu Peng, Tao J Oncol Research Article NM23 expression is closely associated with hepatocellular carcinoma (HCC) recurrence, but the hereditary factors influencing NM23 levels are unknown. Using public database, the diagnostic value of NM23 in HCC was investigated. A total of 424 hepatitis B virus- (HBV-) related HCC patients were enrolled to perform a genome–wide association study for identifying candidate variants associated with NM23 expression level. Additionally, a logistic regression model, haplotypes, and survival analysis were performed in the subsequent analysis. We identified high NM23 expression levels that have a diagnostic accuracy in HCC tissues and had a poor recurrence-free survival in HBV-related HCC patients. Variants near Psoriasis susceptibility 1 candidate 1 (PSORS1C1) and StAR related lipid transdomain containing 3 (STARD3) are associated with NM23 expression. The PSORS1C1 haplotype TGCACA and the STARD3 haplotype GG have favorable cumulative effects on NM23 expression. Further, variants in PSORS1C1 were associated with either overall survival (rs556285588, rs3095301, and rs3131003) only or overall survival and recurrence-free survival (rs560052000 and rs541820233) both in HCC patients. Our findings suggested that variants at the PSORS1C1 and STARD3 loci play an important role in NM23 regulation. Moreover, variants in PSORS1C1 are potential biomarkers for the prediction of postoperative clinical outcomes in HBV-related HCC patients. Thus, variants in PSORS1C1 and STARD3 are associated with NM23 expression and clinical outcomes of HBV-related HCC patients, which may be regarded as potential biomarkers for this disease. Hindawi 2018-12-18 /pmc/articles/PMC6312618/ /pubmed/30662464 http://dx.doi.org/10.1155/2018/6594169 Text en Copyright © 2018 Chengkun Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Chengkun
Han, Chuangye
Wang, Xiangkun
Liao, Xiwen
Liu, Xiaoguang
Qin, Wei
Yu, Long
Zhu, Guangzhi
Su, Hao
Lu, Sicong
Chen, Zhiwei
Yu, Tingdong
Liu, Zhen
Huang, Ketuan
Liu, Zhengtao
Liang, Yu
Huang, Jianlu
Peng, Tao
Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study
title Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study
title_full Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study
title_fullStr Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study
title_full_unstemmed Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study
title_short Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study
title_sort clinical implication and the hereditary factors of nm23 in hepatocellular carcinoma based on bioinformatics analysis and genome–wide association study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312618/
https://www.ncbi.nlm.nih.gov/pubmed/30662464
http://dx.doi.org/10.1155/2018/6594169
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