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On the Colloidal Stability of Spherical Copolymeric Micelles

[Image: see text] Using self-consistent field (SCF) calculations, we systematically quantify the pair interactions between spherical diblock copolymer micelles following a bottom-up approach. From the equilibrium properties of self-assembling micelles at different separation distances, a simple yet...

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Autores principales: García, Álvaro González, Ianiro, Alessandro, Tuinier, Remco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312634/
https://www.ncbi.nlm.nih.gov/pubmed/30613816
http://dx.doi.org/10.1021/acsomega.8b02548
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author García, Álvaro González
Ianiro, Alessandro
Tuinier, Remco
author_facet García, Álvaro González
Ianiro, Alessandro
Tuinier, Remco
author_sort García, Álvaro González
collection PubMed
description [Image: see text] Using self-consistent field (SCF) calculations, we systematically quantify the pair interactions between spherical diblock copolymer micelles following a bottom-up approach. From the equilibrium properties of self-assembling micelles at different separation distances, a simple yet insightful pair interaction can be extracted. The SCF results match with an analytical model based upon closed expressions for the free energy change per diblock copolymer in the micelle. To gain insights into the colloidal stability of dilute micelle suspensions, the second virial coefficient normalized by the undistorted micelle volume (B(2)(*)) is evaluated. For stable micelles (B(2)(*) ≳ −6), we find a weak dependence of B(2)(*) on solvophilic block length for varying core-forming block properties (core solvation and block length). The micelle suspension gets unstable (B(2)(*) ≲ −6) when the corona-forming block crosses Θ-solvent conditions toward poor solvency. In contrast with what is expected from models where the soft nature of the micelle is not taken into account, increasing the effective grafting density of solvophilic tails from the core then leads to colloidal destabilization of the micelle suspension.
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spelling pubmed-63126342019-01-02 On the Colloidal Stability of Spherical Copolymeric Micelles García, Álvaro González Ianiro, Alessandro Tuinier, Remco ACS Omega [Image: see text] Using self-consistent field (SCF) calculations, we systematically quantify the pair interactions between spherical diblock copolymer micelles following a bottom-up approach. From the equilibrium properties of self-assembling micelles at different separation distances, a simple yet insightful pair interaction can be extracted. The SCF results match with an analytical model based upon closed expressions for the free energy change per diblock copolymer in the micelle. To gain insights into the colloidal stability of dilute micelle suspensions, the second virial coefficient normalized by the undistorted micelle volume (B(2)(*)) is evaluated. For stable micelles (B(2)(*) ≳ −6), we find a weak dependence of B(2)(*) on solvophilic block length for varying core-forming block properties (core solvation and block length). The micelle suspension gets unstable (B(2)(*) ≲ −6) when the corona-forming block crosses Θ-solvent conditions toward poor solvency. In contrast with what is expected from models where the soft nature of the micelle is not taken into account, increasing the effective grafting density of solvophilic tails from the core then leads to colloidal destabilization of the micelle suspension. American Chemical Society 2018-12-21 /pmc/articles/PMC6312634/ /pubmed/30613816 http://dx.doi.org/10.1021/acsomega.8b02548 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle García, Álvaro González
Ianiro, Alessandro
Tuinier, Remco
On the Colloidal Stability of Spherical Copolymeric Micelles
title On the Colloidal Stability of Spherical Copolymeric Micelles
title_full On the Colloidal Stability of Spherical Copolymeric Micelles
title_fullStr On the Colloidal Stability of Spherical Copolymeric Micelles
title_full_unstemmed On the Colloidal Stability of Spherical Copolymeric Micelles
title_short On the Colloidal Stability of Spherical Copolymeric Micelles
title_sort on the colloidal stability of spherical copolymeric micelles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312634/
https://www.ncbi.nlm.nih.gov/pubmed/30613816
http://dx.doi.org/10.1021/acsomega.8b02548
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