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A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model

BACKGROUND: We examined whether metoclopramide (MCP), a modulator of dopamine and serotonin receptors, alleviated colitis and had synergistic effects when coadministered with 5-aminosalicylic acid (5-ASA) in an experimental model of colitis. METHODS: MCP azo-linked to 5-ASA (5-[4-chloro-2-{2-(diethy...

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Detalles Bibliográficos
Autores principales:	Yang, Yejin, Kim, Wooseong, Kim, Dayoon, Jeong, Seongkeun, Yoo, Jin-Wook, Jung, Yunjin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312693/ https://www.ncbi.nlm.nih.gov/pubmed/30643389 http://dx.doi.org/10.2147/DDDT.S185257

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