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Cystatin C as a novel predictor of preterm labor in severe preeclampsia
BACKGROUND: The most common cause of acute kidney injury (AKI) in pregnancy is preeclampsia. Serum cystatin C (CysC) is a potential biomarker of early kidney damage as its levels are not disturbed by volume status changes in pregnancy, and serum CysC levels could serve as a replacement for conventio...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Nephrology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312773/ https://www.ncbi.nlm.nih.gov/pubmed/30619689 http://dx.doi.org/10.23876/j.krcp.18.0080 |
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author | Wattanavaekin, Krittanont Kitporntheranunt, Maethaphan Kreepala, Chatchai |
author_facet | Wattanavaekin, Krittanont Kitporntheranunt, Maethaphan Kreepala, Chatchai |
author_sort | Wattanavaekin, Krittanont |
collection | PubMed |
description | BACKGROUND: The most common cause of acute kidney injury (AKI) in pregnancy is preeclampsia. Serum cystatin C (CysC) is a potential biomarker of early kidney damage as its levels are not disturbed by volume status changes in pregnancy, and serum CysC levels could serve as a replacement for conventionally used creatinine. In this study, we investigated the serum levels of CysC in severe preeclampsia cases and the associations between CysC levels and poor obstetric outcomes. METHODS: Our cohort included severe preeclampsia patients with a normal serum creatinine level. Creatinine was measured to calculate estimated glomerular filtration rate (eGFR) based on the Cockcroft and Gault, Modification of Diet in Renal Disease Study (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, while CysC was measured to calculated eGFR based on a CysC-based equation. We then evaluated the correlations between serum CysC level, eGFR, and obstetric outcomes. RESULTS: Twenty-six patients were evaluated of which 38.5% delivered preterm and 30.8% had low-birth weight babies. Unlike creatinine-based eGFR and CysC-based eGFR, serum CysC demonstrate significant negative correlation with gestational age. Receiver operating characteristic curve analysis indicated that serum CysC is a potential biomarker of preterm delivery with a cut-off serum level of 1.48 mg/L with 80% sensitivity and 75% specificity. CONCLUSION: GFR estimation using CysC is likely to be inaccurate in pregnancy. However, we found a significant correlation between preterm delivery and serum CysC level. Our results suggest that serum CysC level has the potential to predict preterm delivery in severe preeclampsia patients. |
format | Online Article Text |
id | pubmed-6312773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-63127732019-01-07 Cystatin C as a novel predictor of preterm labor in severe preeclampsia Wattanavaekin, Krittanont Kitporntheranunt, Maethaphan Kreepala, Chatchai Kidney Res Clin Pract Original Article BACKGROUND: The most common cause of acute kidney injury (AKI) in pregnancy is preeclampsia. Serum cystatin C (CysC) is a potential biomarker of early kidney damage as its levels are not disturbed by volume status changes in pregnancy, and serum CysC levels could serve as a replacement for conventionally used creatinine. In this study, we investigated the serum levels of CysC in severe preeclampsia cases and the associations between CysC levels and poor obstetric outcomes. METHODS: Our cohort included severe preeclampsia patients with a normal serum creatinine level. Creatinine was measured to calculate estimated glomerular filtration rate (eGFR) based on the Cockcroft and Gault, Modification of Diet in Renal Disease Study (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, while CysC was measured to calculated eGFR based on a CysC-based equation. We then evaluated the correlations between serum CysC level, eGFR, and obstetric outcomes. RESULTS: Twenty-six patients were evaluated of which 38.5% delivered preterm and 30.8% had low-birth weight babies. Unlike creatinine-based eGFR and CysC-based eGFR, serum CysC demonstrate significant negative correlation with gestational age. Receiver operating characteristic curve analysis indicated that serum CysC is a potential biomarker of preterm delivery with a cut-off serum level of 1.48 mg/L with 80% sensitivity and 75% specificity. CONCLUSION: GFR estimation using CysC is likely to be inaccurate in pregnancy. However, we found a significant correlation between preterm delivery and serum CysC level. Our results suggest that serum CysC level has the potential to predict preterm delivery in severe preeclampsia patients. Korean Society of Nephrology 2018-12 2018-12-31 /pmc/articles/PMC6312773/ /pubmed/30619689 http://dx.doi.org/10.23876/j.krcp.18.0080 Text en Copyright © 2018 by The Korean Society of Nephrology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Wattanavaekin, Krittanont Kitporntheranunt, Maethaphan Kreepala, Chatchai Cystatin C as a novel predictor of preterm labor in severe preeclampsia |
title | Cystatin C as a novel predictor of preterm labor in severe preeclampsia |
title_full | Cystatin C as a novel predictor of preterm labor in severe preeclampsia |
title_fullStr | Cystatin C as a novel predictor of preterm labor in severe preeclampsia |
title_full_unstemmed | Cystatin C as a novel predictor of preterm labor in severe preeclampsia |
title_short | Cystatin C as a novel predictor of preterm labor in severe preeclampsia |
title_sort | cystatin c as a novel predictor of preterm labor in severe preeclampsia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312773/ https://www.ncbi.nlm.nih.gov/pubmed/30619689 http://dx.doi.org/10.23876/j.krcp.18.0080 |
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