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Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults
PURPOSE: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis. Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), a key factor in the development of RA. This study aimed at evaluating the relationships betw...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Academy of Periodontology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312874/ https://www.ncbi.nlm.nih.gov/pubmed/30619636 http://dx.doi.org/10.5051/jpis.2018.48.6.347 |
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author | Kim, Jin-Hee Choi, In Ah Lee, Joo Youn Kim, Kyoung-Hwa Kim, Sungtae Koo, Ki-Tae Kim, Tae-Il Seol, Yang-Jo Ku, Young Rhyu, In-Chul Song, Yeong Wook Lee, Yong-Moo |
author_facet | Kim, Jin-Hee Choi, In Ah Lee, Joo Youn Kim, Kyoung-Hwa Kim, Sungtae Koo, Ki-Tae Kim, Tae-Il Seol, Yang-Jo Ku, Young Rhyu, In-Chul Song, Yeong Wook Lee, Yong-Moo |
author_sort | Kim, Jin-Hee |
collection | PubMed |
description | PURPOSE: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis. Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), a key factor in the development of RA. This study aimed at evaluating the relationships between the 2 diseases and identifying the clinical implications thereof, with a focus on periodontal pathogens in Korean adults. METHODS: A total of 260 RA patients and 86 age- and sex-matched control patients without arthritis were enrolled in this prospective cross-sectional study. Periodontal indices and the prevalence and amount of periodontal pathogens were compared between the groups. Correlations between periodontal and RA indices were examined, as were correlations between 9 periodontal pathogens and RA indices. RESULTS: The RA group had significantly higher values than the control group for all investigated periodontal indices (P<0.05) except the number of teeth. The gingival index (GI) was correlated with the disease activity score 28 (DAS28) (r=0.125, P=0.049), RA disease duration (r=0.253, P<0.001), erythrocyte sedimentation rate (ESR) (r=0.162, P=0.010), and anti-CCP antibody titer (r=0.205, P=0.004). Probing pocket depth (PPD) was correlated with ESR (r=0.139, P=0.027) and anti-Pg antibody titer (r=0.203, P=0.001). Bleeding on probing (BOP) was correlated with DAS28 (r=0.137, P=0.030), RA disease duration (r=0.202, P=0.001), ESR (r=0.136, P=0.030), anti-Pg antibody titer (r=0.177, P=0.005), and anti-CCP antibody titer (r=0.188, P=0.007). Clinical attachment level (CAL) and periodontitis severity were correlated with anti-Pg antibody titer (the former r=0.201, P=0.002; the latter r=0.175, P=0.006). The quantity of Pg was positively correlated with the serum anti-Pg antibody titer (r=0.148, P=0.020). CONCLUSIONS: The GI, BOP, and PPD showed positive relationships with several RA indices. The anti-Pg antibody titer had positive relationships with PPD, BOP, CAL, and periodontitis severity. Thus, increasing values of periodontal indices could be used as a risk indicator of disease development in RA patients, and an increasing anti-Pg antibody titer could be considered as a warning sign in RA patients suffering with periodontitis. |
format | Online Article Text |
id | pubmed-6312874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Academy of Periodontology |
record_format | MEDLINE/PubMed |
spelling | pubmed-63128742019-01-07 Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults Kim, Jin-Hee Choi, In Ah Lee, Joo Youn Kim, Kyoung-Hwa Kim, Sungtae Koo, Ki-Tae Kim, Tae-Il Seol, Yang-Jo Ku, Young Rhyu, In-Chul Song, Yeong Wook Lee, Yong-Moo J Periodontal Implant Sci Research Article PURPOSE: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis. Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), a key factor in the development of RA. This study aimed at evaluating the relationships between the 2 diseases and identifying the clinical implications thereof, with a focus on periodontal pathogens in Korean adults. METHODS: A total of 260 RA patients and 86 age- and sex-matched control patients without arthritis were enrolled in this prospective cross-sectional study. Periodontal indices and the prevalence and amount of periodontal pathogens were compared between the groups. Correlations between periodontal and RA indices were examined, as were correlations between 9 periodontal pathogens and RA indices. RESULTS: The RA group had significantly higher values than the control group for all investigated periodontal indices (P<0.05) except the number of teeth. The gingival index (GI) was correlated with the disease activity score 28 (DAS28) (r=0.125, P=0.049), RA disease duration (r=0.253, P<0.001), erythrocyte sedimentation rate (ESR) (r=0.162, P=0.010), and anti-CCP antibody titer (r=0.205, P=0.004). Probing pocket depth (PPD) was correlated with ESR (r=0.139, P=0.027) and anti-Pg antibody titer (r=0.203, P=0.001). Bleeding on probing (BOP) was correlated with DAS28 (r=0.137, P=0.030), RA disease duration (r=0.202, P=0.001), ESR (r=0.136, P=0.030), anti-Pg antibody titer (r=0.177, P=0.005), and anti-CCP antibody titer (r=0.188, P=0.007). Clinical attachment level (CAL) and periodontitis severity were correlated with anti-Pg antibody titer (the former r=0.201, P=0.002; the latter r=0.175, P=0.006). The quantity of Pg was positively correlated with the serum anti-Pg antibody titer (r=0.148, P=0.020). CONCLUSIONS: The GI, BOP, and PPD showed positive relationships with several RA indices. The anti-Pg antibody titer had positive relationships with PPD, BOP, CAL, and periodontitis severity. Thus, increasing values of periodontal indices could be used as a risk indicator of disease development in RA patients, and an increasing anti-Pg antibody titer could be considered as a warning sign in RA patients suffering with periodontitis. Korean Academy of Periodontology 2018-12-28 /pmc/articles/PMC6312874/ /pubmed/30619636 http://dx.doi.org/10.5051/jpis.2018.48.6.347 Text en Copyright © 2018. Korean Academy of Periodontology https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/). |
spellingShingle | Research Article Kim, Jin-Hee Choi, In Ah Lee, Joo Youn Kim, Kyoung-Hwa Kim, Sungtae Koo, Ki-Tae Kim, Tae-Il Seol, Yang-Jo Ku, Young Rhyu, In-Chul Song, Yeong Wook Lee, Yong-Moo Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults |
title | Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults |
title_full | Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults |
title_fullStr | Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults |
title_full_unstemmed | Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults |
title_short | Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults |
title_sort | periodontal pathogens and the association between periodontitis and rheumatoid arthritis in korean adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312874/ https://www.ncbi.nlm.nih.gov/pubmed/30619636 http://dx.doi.org/10.5051/jpis.2018.48.6.347 |
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