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Expression pattern and level of ING5 protein in normal and cancer tissues
Inhibitor of growth family 5 (ING5) functions as a type-II tumor suppressor gene and exerts an important role in DNA repair, apoptotic induction, proliferative inhibition, chromatin remodeling and the invasion process. In the present study, immunohistochemistry was performed to characterize the expr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313139/ https://www.ncbi.nlm.nih.gov/pubmed/30655738 http://dx.doi.org/10.3892/ol.2018.9581 |
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author | Yang, Xue-Feng Shen, Dao-Fu Zhao, Shuang Ren, Tian-Ren Gao, Yang Shi, Shuai Wu, Ji-Cheng Sun, Hong-Zhi Zheng, Hua-Chuan |
author_facet | Yang, Xue-Feng Shen, Dao-Fu Zhao, Shuang Ren, Tian-Ren Gao, Yang Shi, Shuai Wu, Ji-Cheng Sun, Hong-Zhi Zheng, Hua-Chuan |
author_sort | Yang, Xue-Feng |
collection | PubMed |
description | Inhibitor of growth family 5 (ING5) functions as a type-II tumor suppressor gene and exerts an important role in DNA repair, apoptotic induction, proliferative inhibition, chromatin remodeling and the invasion process. In the present study, immunohistochemistry was performed to characterize the expression profile of ING5 protein on a tissue microarray containing mouse and human normal tissues, and human cancer tissues, including hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), endometrial (n=96) and lung carcinoma (n=192). In the mouse tissues, ING5 expression was detected in the cytoplasm of neurons, the nephric tubule and glomerulus, alveolar epithelium, gastrointestinal glands, squamous epithelium of the skin and skeletal muscles. By contrast, ING5 was localized to the cell nucleus in breast tissues. In human tissues, ING5 protein was primarily localized in the cytoplasm. However, ING5 was detected in the cytoplasm and nucleus in various types of normal tissues, including the tongue, stomach, intestine, lung and breast. In total, ING5 expression was detected in 400/986 cancer tissues (40.6%). In the majority of cases, ING5 expression was observed to be restricted to the cytoplasm. However, ING5 was also detected in the nucleus in a number of cancer tissues, including gastric, colorectal and lung carcinoma. Notably, ING5 was more frequently expressed in breast (79.9%), colorectal (56.3%) and endometrial carcinoma (50.0%). The incidence of ING5 expression in hepatocellular carcinoma (14.5%) and pancreatic carcinoma (22.6%) was low. These findings indicate that ING5 may be involved in cell regeneration and be associated with colorectal carcinogenesis. |
format | Online Article Text |
id | pubmed-6313139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-63131392019-01-17 Expression pattern and level of ING5 protein in normal and cancer tissues Yang, Xue-Feng Shen, Dao-Fu Zhao, Shuang Ren, Tian-Ren Gao, Yang Shi, Shuai Wu, Ji-Cheng Sun, Hong-Zhi Zheng, Hua-Chuan Oncol Lett Articles Inhibitor of growth family 5 (ING5) functions as a type-II tumor suppressor gene and exerts an important role in DNA repair, apoptotic induction, proliferative inhibition, chromatin remodeling and the invasion process. In the present study, immunohistochemistry was performed to characterize the expression profile of ING5 protein on a tissue microarray containing mouse and human normal tissues, and human cancer tissues, including hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), endometrial (n=96) and lung carcinoma (n=192). In the mouse tissues, ING5 expression was detected in the cytoplasm of neurons, the nephric tubule and glomerulus, alveolar epithelium, gastrointestinal glands, squamous epithelium of the skin and skeletal muscles. By contrast, ING5 was localized to the cell nucleus in breast tissues. In human tissues, ING5 protein was primarily localized in the cytoplasm. However, ING5 was detected in the cytoplasm and nucleus in various types of normal tissues, including the tongue, stomach, intestine, lung and breast. In total, ING5 expression was detected in 400/986 cancer tissues (40.6%). In the majority of cases, ING5 expression was observed to be restricted to the cytoplasm. However, ING5 was also detected in the nucleus in a number of cancer tissues, including gastric, colorectal and lung carcinoma. Notably, ING5 was more frequently expressed in breast (79.9%), colorectal (56.3%) and endometrial carcinoma (50.0%). The incidence of ING5 expression in hepatocellular carcinoma (14.5%) and pancreatic carcinoma (22.6%) was low. These findings indicate that ING5 may be involved in cell regeneration and be associated with colorectal carcinogenesis. D.A. Spandidos 2019-01 2018-10-16 /pmc/articles/PMC6313139/ /pubmed/30655738 http://dx.doi.org/10.3892/ol.2018.9581 Text en Copyright: © Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Yang, Xue-Feng Shen, Dao-Fu Zhao, Shuang Ren, Tian-Ren Gao, Yang Shi, Shuai Wu, Ji-Cheng Sun, Hong-Zhi Zheng, Hua-Chuan Expression pattern and level of ING5 protein in normal and cancer tissues |
title | Expression pattern and level of ING5 protein in normal and cancer tissues |
title_full | Expression pattern and level of ING5 protein in normal and cancer tissues |
title_fullStr | Expression pattern and level of ING5 protein in normal and cancer tissues |
title_full_unstemmed | Expression pattern and level of ING5 protein in normal and cancer tissues |
title_short | Expression pattern and level of ING5 protein in normal and cancer tissues |
title_sort | expression pattern and level of ing5 protein in normal and cancer tissues |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313139/ https://www.ncbi.nlm.nih.gov/pubmed/30655738 http://dx.doi.org/10.3892/ol.2018.9581 |
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