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Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women
Smoking tobacco can impair proper vascular endothelial functioning. This is exhibited through reduced nitric oxide synthesis as well as activity due to accompanying oxidative stress. We examined the relationship between nitric oxide and markers of oxidative stress/antioxidant defense in serum of smo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313314/ https://www.ncbi.nlm.nih.gov/pubmed/30513890 http://dx.doi.org/10.3390/ijerph15122719 |
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author | Chełchowska, Magdalena Ambroszkiewicz, Jadwiga Gajewska, Joanna Mazur, Joanna Lewandowski, Leszek Reśko-Zachara, Marzanna Maciejewski, Tomasz M. |
author_facet | Chełchowska, Magdalena Ambroszkiewicz, Jadwiga Gajewska, Joanna Mazur, Joanna Lewandowski, Leszek Reśko-Zachara, Marzanna Maciejewski, Tomasz M. |
author_sort | Chełchowska, Magdalena |
collection | PubMed |
description | Smoking tobacco can impair proper vascular endothelial functioning. This is exhibited through reduced nitric oxide synthesis as well as activity due to accompanying oxidative stress. We examined the relationship between nitric oxide and markers of oxidative stress/antioxidant defense in serum of smoking and non-smoking pregnant women. Subjects included 99 healthy pregnant women, who were tested for nitric oxide (NO), endothelial (eNOS) and inducible (iNOS) nitric oxide synthase, total oxidant capacity (TOC), and total antioxidant capacity (TAC). NO, eNOS, and TAC serum concentrations were significantly lower (p < 0.005), but iNOS (p < 0.05) and TOC (p < 0.001) were higher in smokers than in non-smokers. Multivariate regression analysis showed associations between NO concentration and eNOS, TAC, and smoking status in the whole group of patients. In the model estimated separately for smokers, the highest impact of eNOS (β = 0.375; p = 0.021) and cotinine (β = −0.323; p = 0.037) was indicated for NO concentration. In the model of non-smokers, eNOS (β = 0.291, p = 0.030) and TAC (β = 0.350; p = 0.015) were important for NO level. Smoking during pregnancy could exacerbate oxidative stress, impair the action of nitric oxide synthases, and adversely affect the balance of oxygen and nitrogen metabolism. Relationships between NO concentrations and TAC in the studied women’s blood can confirm the antioxidant nature of nitric oxide. |
format | Online Article Text |
id | pubmed-6313314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63133142019-06-17 Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women Chełchowska, Magdalena Ambroszkiewicz, Jadwiga Gajewska, Joanna Mazur, Joanna Lewandowski, Leszek Reśko-Zachara, Marzanna Maciejewski, Tomasz M. Int J Environ Res Public Health Article Smoking tobacco can impair proper vascular endothelial functioning. This is exhibited through reduced nitric oxide synthesis as well as activity due to accompanying oxidative stress. We examined the relationship between nitric oxide and markers of oxidative stress/antioxidant defense in serum of smoking and non-smoking pregnant women. Subjects included 99 healthy pregnant women, who were tested for nitric oxide (NO), endothelial (eNOS) and inducible (iNOS) nitric oxide synthase, total oxidant capacity (TOC), and total antioxidant capacity (TAC). NO, eNOS, and TAC serum concentrations were significantly lower (p < 0.005), but iNOS (p < 0.05) and TOC (p < 0.001) were higher in smokers than in non-smokers. Multivariate regression analysis showed associations between NO concentration and eNOS, TAC, and smoking status in the whole group of patients. In the model estimated separately for smokers, the highest impact of eNOS (β = 0.375; p = 0.021) and cotinine (β = −0.323; p = 0.037) was indicated for NO concentration. In the model of non-smokers, eNOS (β = 0.291, p = 0.030) and TAC (β = 0.350; p = 0.015) were important for NO level. Smoking during pregnancy could exacerbate oxidative stress, impair the action of nitric oxide synthases, and adversely affect the balance of oxygen and nitrogen metabolism. Relationships between NO concentrations and TAC in the studied women’s blood can confirm the antioxidant nature of nitric oxide. MDPI 2018-12-03 2018-12 /pmc/articles/PMC6313314/ /pubmed/30513890 http://dx.doi.org/10.3390/ijerph15122719 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chełchowska, Magdalena Ambroszkiewicz, Jadwiga Gajewska, Joanna Mazur, Joanna Lewandowski, Leszek Reśko-Zachara, Marzanna Maciejewski, Tomasz M. Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women |
title | Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women |
title_full | Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women |
title_fullStr | Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women |
title_full_unstemmed | Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women |
title_short | Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women |
title_sort | influence of active exposure to tobacco smoke on nitric oxide status of pregnant women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313314/ https://www.ncbi.nlm.nih.gov/pubmed/30513890 http://dx.doi.org/10.3390/ijerph15122719 |
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