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New Functions of Classical Compounds against Orofacial Inflammatory Lesions

Anti-inflammatory agents have been widely used to ameliorate severe inflammatory symptoms of a number of diseases, and such therapeutics are particularly useful for diseases with intolerable pain without significant mortality. A typical example of this is a disease known as stomatitis; although stom...

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Detalles Bibliográficos
Autores principales: Moritani, Norifumi H., Hara, Emilio Satoshi, Kubota, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313344/
https://www.ncbi.nlm.nih.gov/pubmed/30388792
http://dx.doi.org/10.3390/medicines5040118
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author Moritani, Norifumi H.
Hara, Emilio Satoshi
Kubota, Satoshi
author_facet Moritani, Norifumi H.
Hara, Emilio Satoshi
Kubota, Satoshi
author_sort Moritani, Norifumi H.
collection PubMed
description Anti-inflammatory agents have been widely used to ameliorate severe inflammatory symptoms of a number of diseases, and such therapeutics are particularly useful for diseases with intolerable pain without significant mortality. A typical example of this is a disease known as stomatitis; although stomatitis itself is not a life-threatening disease, it severely impairs the individual’s quality of life, and thus a standard therapeutic strategy for it has already been established. The topical application of a bioactive agent is quite easy, and a strong anti-inflammatory agent can be used without significant adverse effects. In contrast, natural products with relatively mild bioactivity are used for systemic intervention. However, new aspects of classical drugs used in these established therapeutic methods have recently been discovered, which is expanding the utility of these compounds to other oral diseases such as osteoarthritis of temporomandibular joints (TMJ-OA). In this review article, after summarizing the general concept and pathobiology of stomatitis, its established therapeutics are explained. Thereafter, recent advances in the research into related compounds, which is uncovering new biological functions of the agents used therein, are introduced. Indeed, regenerative therapeutics for TMJ-OA may be developed with the classical compounds currently being used.
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spelling pubmed-63133442019-01-07 New Functions of Classical Compounds against Orofacial Inflammatory Lesions Moritani, Norifumi H. Hara, Emilio Satoshi Kubota, Satoshi Medicines (Basel) Review Anti-inflammatory agents have been widely used to ameliorate severe inflammatory symptoms of a number of diseases, and such therapeutics are particularly useful for diseases with intolerable pain without significant mortality. A typical example of this is a disease known as stomatitis; although stomatitis itself is not a life-threatening disease, it severely impairs the individual’s quality of life, and thus a standard therapeutic strategy for it has already been established. The topical application of a bioactive agent is quite easy, and a strong anti-inflammatory agent can be used without significant adverse effects. In contrast, natural products with relatively mild bioactivity are used for systemic intervention. However, new aspects of classical drugs used in these established therapeutic methods have recently been discovered, which is expanding the utility of these compounds to other oral diseases such as osteoarthritis of temporomandibular joints (TMJ-OA). In this review article, after summarizing the general concept and pathobiology of stomatitis, its established therapeutics are explained. Thereafter, recent advances in the research into related compounds, which is uncovering new biological functions of the agents used therein, are introduced. Indeed, regenerative therapeutics for TMJ-OA may be developed with the classical compounds currently being used. MDPI 2018-11-01 /pmc/articles/PMC6313344/ /pubmed/30388792 http://dx.doi.org/10.3390/medicines5040118 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moritani, Norifumi H.
Hara, Emilio Satoshi
Kubota, Satoshi
New Functions of Classical Compounds against Orofacial Inflammatory Lesions
title New Functions of Classical Compounds against Orofacial Inflammatory Lesions
title_full New Functions of Classical Compounds against Orofacial Inflammatory Lesions
title_fullStr New Functions of Classical Compounds against Orofacial Inflammatory Lesions
title_full_unstemmed New Functions of Classical Compounds against Orofacial Inflammatory Lesions
title_short New Functions of Classical Compounds against Orofacial Inflammatory Lesions
title_sort new functions of classical compounds against orofacial inflammatory lesions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313344/
https://www.ncbi.nlm.nih.gov/pubmed/30388792
http://dx.doi.org/10.3390/medicines5040118
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