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Influence of Cyclooxygenase-2 Inhibitors on Kynurenic Acid Production in Rat Brain in Vitro

Significant body of evidence suggests that abnormal kynurenic acid (KYNA) level is involved in the pathophysiology of central nervous system disorders. In the brain, KYNA is synthesized from kynurenine (KYN) by kynurenine aminotransferases (KATs), predominantly by KAT II isoenzyme. Blockage of ionot...

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Detalles Bibliográficos
Autores principales:	Zakrocka, Izabela, Targowska-Duda, Katarzyna M., Wnorowski, Artur, Kocki, Tomasz, Jóźwiak, Krzysztof, Turski, Waldemar A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313367/ https://www.ncbi.nlm.nih.gov/pubmed/30178287 http://dx.doi.org/10.1007/s12640-018-9952-9

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