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Human Dendritic Cells: Ontogeny and Their Subsets in Health and Disease

Dendritic cells (DCs) are a type of cells derived from bone marrow that represent 1% or less of the total hematopoietic cells of any lymphoid organ or of the total cell count of the blood or epithelia. Dendritic cells comprise a heterogeneous population of cells localized in different tissues where...

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Detalles Bibliográficos
Autores principales: Solano-Gálvez, Sandra Georgina, Tovar-Torres, Sonia Margarita, Tron-Gómez, María Sofía, Weiser-Smeke, Ariane Estrella, Álvarez-Hernández, Diego Abelardo, Franyuti-Kelly, Giorgio Alberto, Tapia-Moreno, Mijail, Ibarra, Antonio, Gutiérrez-Kobeh, Laila, Vázquez-López, Rosalino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313400/
https://www.ncbi.nlm.nih.gov/pubmed/30297662
http://dx.doi.org/10.3390/medsci6040088
Descripción
Sumario:Dendritic cells (DCs) are a type of cells derived from bone marrow that represent 1% or less of the total hematopoietic cells of any lymphoid organ or of the total cell count of the blood or epithelia. Dendritic cells comprise a heterogeneous population of cells localized in different tissues where they act as sentinels continuously capturing antigens to present them to T cells. Dendritic cells are uniquely capable of attracting and activating naïve CD4(+) and CD8(+) T cells to initiate and modulate primary immune responses. They have the ability to coordinate tolerance or immunity depending on their activation status, which is why they are also considered as the orchestrating cells of the immune response. The purpose of this review is to provide a general overview of the current knowledge on ontogeny and subsets of human dendritic cells as well as their function and different biological roles.