Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

Background: Alopecia areata (AA) is associated with Interferon- γ (IFN-γ) mediated T-lymphocyte dysfunction and increased circulating Interleukine-17 (IL-17) levels. Epigallocatechin-3-gallate (EGCG) specifically inhibits IFN-γ pathways and unlike Janus Kinase 1 and 2 (JAK1/JAK2) inhibitors (tofacit...

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Detalles Bibliográficos
Autores principales: Hamed, Fatma N., McDonagh, Andrew J. G., Almaghrabi, Sarah, Bakri, Youssef, Messenger, Andrew G., Tazi-Ahnini, Rachid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313664/
https://www.ncbi.nlm.nih.gov/pubmed/30558329
http://dx.doi.org/10.3390/ijerph15122882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313664/
https://www.ncbi.nlm.nih.gov/pubmed/30558329
http://dx.doi.org/10.3390/ijerph15122882

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