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The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection

The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic j...

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Autores principales: Chang, Aileen Y., Tritsch, Sarah, Reid, St. Patrick, Martins, Karen, Encinales, Liliana, Pacheco, Nelly, Amdur, Richard L., Porras-Ramirez, Alexandra, Rico-Mendoza, Alejandro, Li, Guangzhao, Peng, Jin, Firestein, Gary S., Simon, Gary L., Bethony, Jeff M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313749/
https://www.ncbi.nlm.nih.gov/pubmed/30347791
http://dx.doi.org/10.3390/diseases6040095
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author Chang, Aileen Y.
Tritsch, Sarah
Reid, St. Patrick
Martins, Karen
Encinales, Liliana
Pacheco, Nelly
Amdur, Richard L.
Porras-Ramirez, Alexandra
Rico-Mendoza, Alejandro
Li, Guangzhao
Peng, Jin
Firestein, Gary S.
Simon, Gary L.
Bethony, Jeff M.
author_facet Chang, Aileen Y.
Tritsch, Sarah
Reid, St. Patrick
Martins, Karen
Encinales, Liliana
Pacheco, Nelly
Amdur, Richard L.
Porras-Ramirez, Alexandra
Rico-Mendoza, Alejandro
Li, Guangzhao
Peng, Jin
Firestein, Gary S.
Simon, Gary L.
Bethony, Jeff M.
author_sort Chang, Aileen Y.
collection PubMed
description The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.
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spelling pubmed-63137492019-01-04 The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection Chang, Aileen Y. Tritsch, Sarah Reid, St. Patrick Martins, Karen Encinales, Liliana Pacheco, Nelly Amdur, Richard L. Porras-Ramirez, Alexandra Rico-Mendoza, Alejandro Li, Guangzhao Peng, Jin Firestein, Gary S. Simon, Gary L. Bethony, Jeff M. Diseases Article The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis. MDPI 2018-10-20 /pmc/articles/PMC6313749/ /pubmed/30347791 http://dx.doi.org/10.3390/diseases6040095 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Aileen Y.
Tritsch, Sarah
Reid, St. Patrick
Martins, Karen
Encinales, Liliana
Pacheco, Nelly
Amdur, Richard L.
Porras-Ramirez, Alexandra
Rico-Mendoza, Alejandro
Li, Guangzhao
Peng, Jin
Firestein, Gary S.
Simon, Gary L.
Bethony, Jeff M.
The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection
title The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection
title_full The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection
title_fullStr The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection
title_full_unstemmed The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection
title_short The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection
title_sort cytokine profile in acute chikungunya infection is predictive of chronic arthritis 20 months post infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313749/
https://www.ncbi.nlm.nih.gov/pubmed/30347791
http://dx.doi.org/10.3390/diseases6040095
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