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The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection
The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic j...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313749/ https://www.ncbi.nlm.nih.gov/pubmed/30347791 http://dx.doi.org/10.3390/diseases6040095 |
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author | Chang, Aileen Y. Tritsch, Sarah Reid, St. Patrick Martins, Karen Encinales, Liliana Pacheco, Nelly Amdur, Richard L. Porras-Ramirez, Alexandra Rico-Mendoza, Alejandro Li, Guangzhao Peng, Jin Firestein, Gary S. Simon, Gary L. Bethony, Jeff M. |
author_facet | Chang, Aileen Y. Tritsch, Sarah Reid, St. Patrick Martins, Karen Encinales, Liliana Pacheco, Nelly Amdur, Richard L. Porras-Ramirez, Alexandra Rico-Mendoza, Alejandro Li, Guangzhao Peng, Jin Firestein, Gary S. Simon, Gary L. Bethony, Jeff M. |
author_sort | Chang, Aileen Y. |
collection | PubMed |
description | The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis. |
format | Online Article Text |
id | pubmed-6313749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63137492019-01-04 The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection Chang, Aileen Y. Tritsch, Sarah Reid, St. Patrick Martins, Karen Encinales, Liliana Pacheco, Nelly Amdur, Richard L. Porras-Ramirez, Alexandra Rico-Mendoza, Alejandro Li, Guangzhao Peng, Jin Firestein, Gary S. Simon, Gary L. Bethony, Jeff M. Diseases Article The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis. MDPI 2018-10-20 /pmc/articles/PMC6313749/ /pubmed/30347791 http://dx.doi.org/10.3390/diseases6040095 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chang, Aileen Y. Tritsch, Sarah Reid, St. Patrick Martins, Karen Encinales, Liliana Pacheco, Nelly Amdur, Richard L. Porras-Ramirez, Alexandra Rico-Mendoza, Alejandro Li, Guangzhao Peng, Jin Firestein, Gary S. Simon, Gary L. Bethony, Jeff M. The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection |
title | The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection |
title_full | The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection |
title_fullStr | The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection |
title_full_unstemmed | The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection |
title_short | The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection |
title_sort | cytokine profile in acute chikungunya infection is predictive of chronic arthritis 20 months post infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313749/ https://www.ncbi.nlm.nih.gov/pubmed/30347791 http://dx.doi.org/10.3390/diseases6040095 |
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