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Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology

Case-control studies on malignant sinonasal tumors and occupational risk factors are generally weakened by non-occupational confounders and the selection of suitable controls. This study aimed to confirm the association between sinonasal malignant tumors and patients’ occupations with consideration...

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Autores principales: Emanuelli, Enzo, Comiati, Vera, Cazzador, Diego, Schiavo, Gloria, Alexandre, Enrico, Fedeli, Ugo, Frasson, Giuliana, Zanon, Alessia, Martini, Alessandro, Scapellato, Maria Luisa, Mastrangelo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313789/
https://www.ncbi.nlm.nih.gov/pubmed/30562946
http://dx.doi.org/10.3390/ijerph15122887
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author Emanuelli, Enzo
Comiati, Vera
Cazzador, Diego
Schiavo, Gloria
Alexandre, Enrico
Fedeli, Ugo
Frasson, Giuliana
Zanon, Alessia
Martini, Alessandro
Scapellato, Maria Luisa
Mastrangelo, Giuseppe
author_facet Emanuelli, Enzo
Comiati, Vera
Cazzador, Diego
Schiavo, Gloria
Alexandre, Enrico
Fedeli, Ugo
Frasson, Giuliana
Zanon, Alessia
Martini, Alessandro
Scapellato, Maria Luisa
Mastrangelo, Giuseppe
author_sort Emanuelli, Enzo
collection PubMed
description Case-control studies on malignant sinonasal tumors and occupational risk factors are generally weakened by non-occupational confounders and the selection of suitable controls. This study aimed to confirm the association between sinonasal malignant tumors and patients’ occupations with consideration for sinonasal inverted papillomas (SNIPs) as a control group. Thirty-two patients affected by adenocarcinoma (ADC) and 21 non-adenocarcinoma epithelial tumors (NAETs) were compared to 65 patients diagnosed with SNIPs. All patients were recruited in the same clinical setting between 2004 and 2016. A questionnaire was used to collect information on non-occupational factors (age, sex, smoking, allergies, and chronic sinusitis) and occupations (wood- and leather-related occupations, textile industry, metal working). Odds ratios (OR) with 95% confidence intervals (CI) associated with selected occupations were obtained by a multinomial and exact logistic regression. Between the three groups of patients, SNIP patients were significantly younger than ADC patients (p = 0.026). The risk of NAET increased in woodworkers (OR = 9.42; CI = 1.94–45.6) and metal workers (OR = 5.65; CI = 1.12–28.6). The risk of ADC increased in wood (OR = 86.3; CI = 15.2–488) and leather workers (OR = 119.4; CI = 11.3–1258). On the exact logistic regression, the OR associated to the textile industry was 9.32 (95%CI = 1.10–Inf) for ADC, and 7.21 (95%CI = 0.55–Inf) for NAET. Comparing sinonasal malignant tumors with controls recruited from the same clinical setting allowed demonstrating an increased risk associated with multiple occupations. Well-matched samples of cases and controls reduced the confounding bias and increased the strength of the association.
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spelling pubmed-63137892019-06-17 Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology Emanuelli, Enzo Comiati, Vera Cazzador, Diego Schiavo, Gloria Alexandre, Enrico Fedeli, Ugo Frasson, Giuliana Zanon, Alessia Martini, Alessandro Scapellato, Maria Luisa Mastrangelo, Giuseppe Int J Environ Res Public Health Article Case-control studies on malignant sinonasal tumors and occupational risk factors are generally weakened by non-occupational confounders and the selection of suitable controls. This study aimed to confirm the association between sinonasal malignant tumors and patients’ occupations with consideration for sinonasal inverted papillomas (SNIPs) as a control group. Thirty-two patients affected by adenocarcinoma (ADC) and 21 non-adenocarcinoma epithelial tumors (NAETs) were compared to 65 patients diagnosed with SNIPs. All patients were recruited in the same clinical setting between 2004 and 2016. A questionnaire was used to collect information on non-occupational factors (age, sex, smoking, allergies, and chronic sinusitis) and occupations (wood- and leather-related occupations, textile industry, metal working). Odds ratios (OR) with 95% confidence intervals (CI) associated with selected occupations were obtained by a multinomial and exact logistic regression. Between the three groups of patients, SNIP patients were significantly younger than ADC patients (p = 0.026). The risk of NAET increased in woodworkers (OR = 9.42; CI = 1.94–45.6) and metal workers (OR = 5.65; CI = 1.12–28.6). The risk of ADC increased in wood (OR = 86.3; CI = 15.2–488) and leather workers (OR = 119.4; CI = 11.3–1258). On the exact logistic regression, the OR associated to the textile industry was 9.32 (95%CI = 1.10–Inf) for ADC, and 7.21 (95%CI = 0.55–Inf) for NAET. Comparing sinonasal malignant tumors with controls recruited from the same clinical setting allowed demonstrating an increased risk associated with multiple occupations. Well-matched samples of cases and controls reduced the confounding bias and increased the strength of the association. MDPI 2018-12-17 2018-12 /pmc/articles/PMC6313789/ /pubmed/30562946 http://dx.doi.org/10.3390/ijerph15122887 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Emanuelli, Enzo
Comiati, Vera
Cazzador, Diego
Schiavo, Gloria
Alexandre, Enrico
Fedeli, Ugo
Frasson, Giuliana
Zanon, Alessia
Martini, Alessandro
Scapellato, Maria Luisa
Mastrangelo, Giuseppe
Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
title Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
title_full Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
title_fullStr Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
title_full_unstemmed Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
title_short Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
title_sort malignant versus benign tumors of the sinonasal cavity: a case-control study on occupational etiology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313789/
https://www.ncbi.nlm.nih.gov/pubmed/30562946
http://dx.doi.org/10.3390/ijerph15122887
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