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Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology
Case-control studies on malignant sinonasal tumors and occupational risk factors are generally weakened by non-occupational confounders and the selection of suitable controls. This study aimed to confirm the association between sinonasal malignant tumors and patients’ occupations with consideration...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313789/ https://www.ncbi.nlm.nih.gov/pubmed/30562946 http://dx.doi.org/10.3390/ijerph15122887 |
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author | Emanuelli, Enzo Comiati, Vera Cazzador, Diego Schiavo, Gloria Alexandre, Enrico Fedeli, Ugo Frasson, Giuliana Zanon, Alessia Martini, Alessandro Scapellato, Maria Luisa Mastrangelo, Giuseppe |
author_facet | Emanuelli, Enzo Comiati, Vera Cazzador, Diego Schiavo, Gloria Alexandre, Enrico Fedeli, Ugo Frasson, Giuliana Zanon, Alessia Martini, Alessandro Scapellato, Maria Luisa Mastrangelo, Giuseppe |
author_sort | Emanuelli, Enzo |
collection | PubMed |
description | Case-control studies on malignant sinonasal tumors and occupational risk factors are generally weakened by non-occupational confounders and the selection of suitable controls. This study aimed to confirm the association between sinonasal malignant tumors and patients’ occupations with consideration for sinonasal inverted papillomas (SNIPs) as a control group. Thirty-two patients affected by adenocarcinoma (ADC) and 21 non-adenocarcinoma epithelial tumors (NAETs) were compared to 65 patients diagnosed with SNIPs. All patients were recruited in the same clinical setting between 2004 and 2016. A questionnaire was used to collect information on non-occupational factors (age, sex, smoking, allergies, and chronic sinusitis) and occupations (wood- and leather-related occupations, textile industry, metal working). Odds ratios (OR) with 95% confidence intervals (CI) associated with selected occupations were obtained by a multinomial and exact logistic regression. Between the three groups of patients, SNIP patients were significantly younger than ADC patients (p = 0.026). The risk of NAET increased in woodworkers (OR = 9.42; CI = 1.94–45.6) and metal workers (OR = 5.65; CI = 1.12–28.6). The risk of ADC increased in wood (OR = 86.3; CI = 15.2–488) and leather workers (OR = 119.4; CI = 11.3–1258). On the exact logistic regression, the OR associated to the textile industry was 9.32 (95%CI = 1.10–Inf) for ADC, and 7.21 (95%CI = 0.55–Inf) for NAET. Comparing sinonasal malignant tumors with controls recruited from the same clinical setting allowed demonstrating an increased risk associated with multiple occupations. Well-matched samples of cases and controls reduced the confounding bias and increased the strength of the association. |
format | Online Article Text |
id | pubmed-6313789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63137892019-06-17 Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology Emanuelli, Enzo Comiati, Vera Cazzador, Diego Schiavo, Gloria Alexandre, Enrico Fedeli, Ugo Frasson, Giuliana Zanon, Alessia Martini, Alessandro Scapellato, Maria Luisa Mastrangelo, Giuseppe Int J Environ Res Public Health Article Case-control studies on malignant sinonasal tumors and occupational risk factors are generally weakened by non-occupational confounders and the selection of suitable controls. This study aimed to confirm the association between sinonasal malignant tumors and patients’ occupations with consideration for sinonasal inverted papillomas (SNIPs) as a control group. Thirty-two patients affected by adenocarcinoma (ADC) and 21 non-adenocarcinoma epithelial tumors (NAETs) were compared to 65 patients diagnosed with SNIPs. All patients were recruited in the same clinical setting between 2004 and 2016. A questionnaire was used to collect information on non-occupational factors (age, sex, smoking, allergies, and chronic sinusitis) and occupations (wood- and leather-related occupations, textile industry, metal working). Odds ratios (OR) with 95% confidence intervals (CI) associated with selected occupations were obtained by a multinomial and exact logistic regression. Between the three groups of patients, SNIP patients were significantly younger than ADC patients (p = 0.026). The risk of NAET increased in woodworkers (OR = 9.42; CI = 1.94–45.6) and metal workers (OR = 5.65; CI = 1.12–28.6). The risk of ADC increased in wood (OR = 86.3; CI = 15.2–488) and leather workers (OR = 119.4; CI = 11.3–1258). On the exact logistic regression, the OR associated to the textile industry was 9.32 (95%CI = 1.10–Inf) for ADC, and 7.21 (95%CI = 0.55–Inf) for NAET. Comparing sinonasal malignant tumors with controls recruited from the same clinical setting allowed demonstrating an increased risk associated with multiple occupations. Well-matched samples of cases and controls reduced the confounding bias and increased the strength of the association. MDPI 2018-12-17 2018-12 /pmc/articles/PMC6313789/ /pubmed/30562946 http://dx.doi.org/10.3390/ijerph15122887 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Emanuelli, Enzo Comiati, Vera Cazzador, Diego Schiavo, Gloria Alexandre, Enrico Fedeli, Ugo Frasson, Giuliana Zanon, Alessia Martini, Alessandro Scapellato, Maria Luisa Mastrangelo, Giuseppe Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology |
title | Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology |
title_full | Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology |
title_fullStr | Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology |
title_full_unstemmed | Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology |
title_short | Malignant Versus Benign Tumors of the Sinonasal Cavity: A Case-Control Study on Occupational Etiology |
title_sort | malignant versus benign tumors of the sinonasal cavity: a case-control study on occupational etiology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313789/ https://www.ncbi.nlm.nih.gov/pubmed/30562946 http://dx.doi.org/10.3390/ijerph15122887 |
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