Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells

PURPOSE: The activation of ROS-NLRP3-IL-1β signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis. The current study aims to investigate whether calcitriol, the active metabolite of vitamin D(3), could protect...

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Detalles Bibliográficos
Autores principales: Dai, Yiqin, Zhang, Jing, Xiang, Jun, Li, Yue, Wu, Dan, Xu, Jianjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313824/
https://www.ncbi.nlm.nih.gov/pubmed/30611121
http://dx.doi.org/10.1016/j.redox.2018.101093

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