The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily

The Ribonuclease A Superfamily is composed of cationic peptides that are secreted by immune cells and epithelial tissues. Although their physiological roles are unclear, several members of the vertebrate Ribonuclease A Superfamily demonstrate antimicrobial and immune modulation activities. The objec...

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Detalles Bibliográficos
Autores principales: Schwartz, Laura, Cohen, Ariel, Thomas, Jason, Spencer, John David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313885/
https://www.ncbi.nlm.nih.gov/pubmed/30463297
http://dx.doi.org/10.3390/vaccines6040076
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author Schwartz, Laura
Cohen, Ariel
Thomas, Jason
Spencer, John David
author_facet Schwartz, Laura
Cohen, Ariel
Thomas, Jason
Spencer, John David
author_sort Schwartz, Laura
collection PubMed
description The Ribonuclease A Superfamily is composed of cationic peptides that are secreted by immune cells and epithelial tissues. Although their physiological roles are unclear, several members of the vertebrate Ribonuclease A Superfamily demonstrate antimicrobial and immune modulation activities. The objective of this review is to provide an overview of the published literature on the Ribonuclease A Superfamily with an emphasis on each peptide’s regulation, antimicrobial properties, and immunomodulatory functions. As additional insights emerge regarding the mechanisms in which these ribonucleases eradicate invading pathogens and modulate immune function, these ribonucleases may have the potential to be developed as a novel class of therapeutics for some human diseases.
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spelling pubmed-63138852019-01-07 The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily Schwartz, Laura Cohen, Ariel Thomas, Jason Spencer, John David Vaccines (Basel) Review The Ribonuclease A Superfamily is composed of cationic peptides that are secreted by immune cells and epithelial tissues. Although their physiological roles are unclear, several members of the vertebrate Ribonuclease A Superfamily demonstrate antimicrobial and immune modulation activities. The objective of this review is to provide an overview of the published literature on the Ribonuclease A Superfamily with an emphasis on each peptide’s regulation, antimicrobial properties, and immunomodulatory functions. As additional insights emerge regarding the mechanisms in which these ribonucleases eradicate invading pathogens and modulate immune function, these ribonucleases may have the potential to be developed as a novel class of therapeutics for some human diseases. MDPI 2018-11-20 /pmc/articles/PMC6313885/ /pubmed/30463297 http://dx.doi.org/10.3390/vaccines6040076 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schwartz, Laura
Cohen, Ariel
Thomas, Jason
Spencer, John David
The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily
title The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily
title_full The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily
title_fullStr The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily
title_full_unstemmed The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily
title_short The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily
title_sort immunomodulatory and antimicrobial properties of the vertebrate ribonuclease a superfamily
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313885/
https://www.ncbi.nlm.nih.gov/pubmed/30463297
http://dx.doi.org/10.3390/vaccines6040076
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