Fast Tracks and Roadblocks for Zika Vaccines

In early 2014, a relatively obscure virus, the Zika virus, made headlines worldwide following an increase in the number of congenital malformations. Since then, research on Zika virus, treatment and vaccines have progressed swiftly with various drugs being repurposed and vaccines heading into clinic...

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Detalles Bibliográficos
Autores principales: Ghaffar, Khairunnisa Abdul, Ng, Lisa F.P., Renia, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313897/
https://www.ncbi.nlm.nih.gov/pubmed/30469444
http://dx.doi.org/10.3390/vaccines6040077
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author Ghaffar, Khairunnisa Abdul
Ng, Lisa F.P.
Renia, Laurent
author_facet Ghaffar, Khairunnisa Abdul
Ng, Lisa F.P.
Renia, Laurent
author_sort Ghaffar, Khairunnisa Abdul
collection PubMed
description In early 2014, a relatively obscure virus, the Zika virus, made headlines worldwide following an increase in the number of congenital malformations. Since then, research on Zika virus, treatment and vaccines have progressed swiftly with various drugs being repurposed and vaccines heading into clinical trials. Nonetheless, the need for a vaccine is crucial in order to eradicate this re-emerging arthropod-borne virus which remained silent since its first discovery in 1947. In this review, we focused on how the inconspicuous virus managed to spread, the key immunological factors required for a vaccine and the various vaccine platforms that are currently being studied.
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spelling pubmed-63138972019-01-07 Fast Tracks and Roadblocks for Zika Vaccines Ghaffar, Khairunnisa Abdul Ng, Lisa F.P. Renia, Laurent Vaccines (Basel) Review In early 2014, a relatively obscure virus, the Zika virus, made headlines worldwide following an increase in the number of congenital malformations. Since then, research on Zika virus, treatment and vaccines have progressed swiftly with various drugs being repurposed and vaccines heading into clinical trials. Nonetheless, the need for a vaccine is crucial in order to eradicate this re-emerging arthropod-borne virus which remained silent since its first discovery in 1947. In this review, we focused on how the inconspicuous virus managed to spread, the key immunological factors required for a vaccine and the various vaccine platforms that are currently being studied. MDPI 2018-11-21 /pmc/articles/PMC6313897/ /pubmed/30469444 http://dx.doi.org/10.3390/vaccines6040077 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghaffar, Khairunnisa Abdul
Ng, Lisa F.P.
Renia, Laurent
Fast Tracks and Roadblocks for Zika Vaccines
title Fast Tracks and Roadblocks for Zika Vaccines
title_full Fast Tracks and Roadblocks for Zika Vaccines
title_fullStr Fast Tracks and Roadblocks for Zika Vaccines
title_full_unstemmed Fast Tracks and Roadblocks for Zika Vaccines
title_short Fast Tracks and Roadblocks for Zika Vaccines
title_sort fast tracks and roadblocks for zika vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313897/
https://www.ncbi.nlm.nih.gov/pubmed/30469444
http://dx.doi.org/10.3390/vaccines6040077
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