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Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves

Shiga toxin-producing Escherichia coli, like E. coli O157:H7, are important human and animal pathogens. Naturally-acquired E. coli O157:H7 infections occur in numerous species but, particularly, cattle have been identified as a significant reservoir for human cases. E. coli O157:H7 are isolated from...

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Autores principales: Antaki-Zukoski, Elizabeth M., Li, Xunde, Pesavento, Patricia A., Nguyen, Tran H. B., Hoar, Bruce R., Atwill, Edward R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313898/
https://www.ncbi.nlm.nih.gov/pubmed/30326606
http://dx.doi.org/10.3390/vetsci5040088
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author Antaki-Zukoski, Elizabeth M.
Li, Xunde
Pesavento, Patricia A.
Nguyen, Tran H. B.
Hoar, Bruce R.
Atwill, Edward R.
author_facet Antaki-Zukoski, Elizabeth M.
Li, Xunde
Pesavento, Patricia A.
Nguyen, Tran H. B.
Hoar, Bruce R.
Atwill, Edward R.
author_sort Antaki-Zukoski, Elizabeth M.
collection PubMed
description Shiga toxin-producing Escherichia coli, like E. coli O157:H7, are important human and animal pathogens. Naturally-acquired E. coli O157:H7 infections occur in numerous species but, particularly, cattle have been identified as a significant reservoir for human cases. E. coli O157:H7 are isolated from a number of domestic and wild animals, including rodents that share a living space with cattle. These Shiga toxin-producing E. coli O157:H7 strains can be highly virulent in humans, but little is known about the sequelae of interspecies transfer. In a group of neonatal calves, we determined the differences in colonization patterns and lesions associated with infection using either a wildlife or bovine E. coli O157:H7 strain. In calves challenged with the wildlife E. coli O157:H7 strain, the large (descending) colon was solely colonized, which differed substantially from the calves inoculated with the bovine E. coli O157:H7 strain, where the spiral colon was the principal target of infection. This study also demonstrated that while both interspecies- and intraspecies-derived E. coli O157:H7 can infect young calves, the distribution and severity differs.
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spelling pubmed-63138982019-01-07 Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves Antaki-Zukoski, Elizabeth M. Li, Xunde Pesavento, Patricia A. Nguyen, Tran H. B. Hoar, Bruce R. Atwill, Edward R. Vet Sci Article Shiga toxin-producing Escherichia coli, like E. coli O157:H7, are important human and animal pathogens. Naturally-acquired E. coli O157:H7 infections occur in numerous species but, particularly, cattle have been identified as a significant reservoir for human cases. E. coli O157:H7 are isolated from a number of domestic and wild animals, including rodents that share a living space with cattle. These Shiga toxin-producing E. coli O157:H7 strains can be highly virulent in humans, but little is known about the sequelae of interspecies transfer. In a group of neonatal calves, we determined the differences in colonization patterns and lesions associated with infection using either a wildlife or bovine E. coli O157:H7 strain. In calves challenged with the wildlife E. coli O157:H7 strain, the large (descending) colon was solely colonized, which differed substantially from the calves inoculated with the bovine E. coli O157:H7 strain, where the spiral colon was the principal target of infection. This study also demonstrated that while both interspecies- and intraspecies-derived E. coli O157:H7 can infect young calves, the distribution and severity differs. MDPI 2018-10-15 /pmc/articles/PMC6313898/ /pubmed/30326606 http://dx.doi.org/10.3390/vetsci5040088 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Antaki-Zukoski, Elizabeth M.
Li, Xunde
Pesavento, Patricia A.
Nguyen, Tran H. B.
Hoar, Bruce R.
Atwill, Edward R.
Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves
title Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves
title_full Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves
title_fullStr Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves
title_full_unstemmed Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves
title_short Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves
title_sort comparative pathogenicity of wildlife and bovine escherichia coli o157:h7 strains in experimentally inoculated neonatal jersey calves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313898/
https://www.ncbi.nlm.nih.gov/pubmed/30326606
http://dx.doi.org/10.3390/vetsci5040088
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