Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA

It is well accepted that treatment of chronic pain with morphine leads to μ opioid receptor (MOR) desensitization and the development of morphine tolerance. MOR activation by the selective peptide agonist, D-Ala2, N-MePhe4, Gly-ol]-enkephalin(DAMGO), leads to robust G protein receptor kinase activat...

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Detalles Bibliográficos
Autores principales: Pena, Darlene A., Duarte, Mariana Lemos, Pramio, Dimitrius T., Devi, Lakshmi A., Schechtman, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313901/
https://www.ncbi.nlm.nih.gov/pubmed/30301203
http://dx.doi.org/10.3390/proteomes6040039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313901/
https://www.ncbi.nlm.nih.gov/pubmed/30301203
http://dx.doi.org/10.3390/proteomes6040039

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