Memory T Cells in Flavivirus Vaccination

Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or...

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Detalles Bibliográficos
Autores principales: Li, Guangyu, Teleki, Cody, Wang, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313919/
https://www.ncbi.nlm.nih.gov/pubmed/30340377
http://dx.doi.org/10.3390/vaccines6040073
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author Li, Guangyu
Teleki, Cody
Wang, Tian
author_facet Li, Guangyu
Teleki, Cody
Wang, Tian
author_sort Li, Guangyu
collection PubMed
description Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines.
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spelling pubmed-63139192019-01-07 Memory T Cells in Flavivirus Vaccination Li, Guangyu Teleki, Cody Wang, Tian Vaccines (Basel) Review Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines. MDPI 2018-10-18 /pmc/articles/PMC6313919/ /pubmed/30340377 http://dx.doi.org/10.3390/vaccines6040073 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Guangyu
Teleki, Cody
Wang, Tian
Memory T Cells in Flavivirus Vaccination
title Memory T Cells in Flavivirus Vaccination
title_full Memory T Cells in Flavivirus Vaccination
title_fullStr Memory T Cells in Flavivirus Vaccination
title_full_unstemmed Memory T Cells in Flavivirus Vaccination
title_short Memory T Cells in Flavivirus Vaccination
title_sort memory t cells in flavivirus vaccination
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313919/
https://www.ncbi.nlm.nih.gov/pubmed/30340377
http://dx.doi.org/10.3390/vaccines6040073
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