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Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography

PURPOSE: To evaluate the relationship between angle dimensions assessed by gonioscopy or EyeCam and anterior segment optical coherence tomography (AS-OCT). METHODS: Subjects aged 50 years or older were recruited from the Chinese American Eye Study (CHES). Each subject underwent a complete ocular exa...

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Autores principales: Xu, Benjamin Y., Pardeshi, Anmol A., Burkemper, Bruce, Richter, Grace M., Lin, Shan C., McKean-Cowdin, Roberta, Varma, Rohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314106/
https://www.ncbi.nlm.nih.gov/pubmed/30619653
http://dx.doi.org/10.1167/tvst.7.6.33
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author Xu, Benjamin Y.
Pardeshi, Anmol A.
Burkemper, Bruce
Richter, Grace M.
Lin, Shan C.
McKean-Cowdin, Roberta
Varma, Rohit
author_facet Xu, Benjamin Y.
Pardeshi, Anmol A.
Burkemper, Bruce
Richter, Grace M.
Lin, Shan C.
McKean-Cowdin, Roberta
Varma, Rohit
author_sort Xu, Benjamin Y.
collection PubMed
description PURPOSE: To evaluate the relationship between angle dimensions assessed by gonioscopy or EyeCam and anterior segment optical coherence tomography (AS-OCT). METHODS: Subjects aged 50 years or older were recruited from the Chinese American Eye Study (CHES). Each subject underwent a complete ocular exam, including gonioscopy, AS-OCT, and EyeCam. Angle closure was defined as three or more quadrants in which pigmented trabecular meshwork could not be visualized. Angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular iris angle (TIA), and scleral spur angle (SSA) were measured in each AS-OCT image. RESULTS: 709 eyes (272 angle closure, 437 open angle) from 709 subjects were analyzed. Mean gonioscopy and EyeCam grades tended to increase as AS-OCT measurements increased. There were strong correlations overall between AS-OCT measurements and gonioscopy (r > 0.73) and EyeCam (r > 0.68) grades. However, correlations with AS-OCT measurements were weak for gonioscopy (r < 0.38) and EyeCam (r < to 0.27) among eyes with angle closure. Mean AS-OCT measurements differed for eyes with Shaffer grade 0 in all four quadrants among eyes with varying degrees of angle closure on gonioscopy (P < 0.01) but did not differ among eyes with varying degrees of angle closure on EyeCam (P > 0.27). CONCLUSIONS: Angle assessments by gonioscopy and EyeCam are weakly related to angle dimensions in eyes with angle closure. TRANSLATIONAL RELEVANCE: AS-OCT imaging raises concerns about current clinical methods that rely on direct visualization of ACA structures to assess the degree of angle closure.
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spelling pubmed-63141062019-01-07 Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography Xu, Benjamin Y. Pardeshi, Anmol A. Burkemper, Bruce Richter, Grace M. Lin, Shan C. McKean-Cowdin, Roberta Varma, Rohit Transl Vis Sci Technol Articles PURPOSE: To evaluate the relationship between angle dimensions assessed by gonioscopy or EyeCam and anterior segment optical coherence tomography (AS-OCT). METHODS: Subjects aged 50 years or older were recruited from the Chinese American Eye Study (CHES). Each subject underwent a complete ocular exam, including gonioscopy, AS-OCT, and EyeCam. Angle closure was defined as three or more quadrants in which pigmented trabecular meshwork could not be visualized. Angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular iris angle (TIA), and scleral spur angle (SSA) were measured in each AS-OCT image. RESULTS: 709 eyes (272 angle closure, 437 open angle) from 709 subjects were analyzed. Mean gonioscopy and EyeCam grades tended to increase as AS-OCT measurements increased. There were strong correlations overall between AS-OCT measurements and gonioscopy (r > 0.73) and EyeCam (r > 0.68) grades. However, correlations with AS-OCT measurements were weak for gonioscopy (r < 0.38) and EyeCam (r < to 0.27) among eyes with angle closure. Mean AS-OCT measurements differed for eyes with Shaffer grade 0 in all four quadrants among eyes with varying degrees of angle closure on gonioscopy (P < 0.01) but did not differ among eyes with varying degrees of angle closure on EyeCam (P > 0.27). CONCLUSIONS: Angle assessments by gonioscopy and EyeCam are weakly related to angle dimensions in eyes with angle closure. TRANSLATIONAL RELEVANCE: AS-OCT imaging raises concerns about current clinical methods that rely on direct visualization of ACA structures to assess the degree of angle closure. The Association for Research in Vision and Ophthalmology 2018-12-27 /pmc/articles/PMC6314106/ /pubmed/30619653 http://dx.doi.org/10.1167/tvst.7.6.33 Text en Copyright 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Articles
Xu, Benjamin Y.
Pardeshi, Anmol A.
Burkemper, Bruce
Richter, Grace M.
Lin, Shan C.
McKean-Cowdin, Roberta
Varma, Rohit
Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography
title Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography
title_full Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography
title_fullStr Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography
title_full_unstemmed Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography
title_short Quantitative Evaluation of Gonioscopic and EyeCam Assessments of Angle Dimensions Using Anterior Segment Optical Coherence Tomography
title_sort quantitative evaluation of gonioscopic and eyecam assessments of angle dimensions using anterior segment optical coherence tomography
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314106/
https://www.ncbi.nlm.nih.gov/pubmed/30619653
http://dx.doi.org/10.1167/tvst.7.6.33
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