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Recombinant prion protein vaccination of transgenic elk PrP mice and reindeer overcomes self-tolerance and protects mice against chronic wasting disease

Chronic wasting disease (CWD) is a fatal neurodegenerative disease that affects cervids in North America and now Europe. No effective measures are available to control CWD. We hypothesized that active vaccination with homologous and aggregation-prone recombinant prion protein (PrP) could overcome se...

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Detalles Bibliográficos
Autores principales:	Abdelaziz, Dalia H., Thapa, Simrika, Brandon, Jenna, Maybee, Justine, Vankuppeveld, Lauren, McCorkell, Robert, Schätzl, Hermann M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314114/ https://www.ncbi.nlm.nih.gov/pubmed/30397182 http://dx.doi.org/10.1074/jbc.RA118.004810

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