An Intratumor Pharmacokinetic/Pharmacodynamic Model for the Hypoxia-Activated Prodrug Evofosfamide (TH-302): Monotherapy Activity is Not Dependent on a Bystander Effect()()

Tumor hypoxia contributes to resistance to anticancer therapies. Hypoxia-activated prodrugs (HAPs) selectively target hypoxic cells and their activity can extend to well-oxygenated areas of tumors via diffusion of active metabolites. This type of bystander effect has been suggested to be responsible...

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Detalles Bibliográficos
Autores principales: Hong, Cho Rong, Wilson, William R., Hicks, Kevin O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314220/
https://www.ncbi.nlm.nih.gov/pubmed/30591421
http://dx.doi.org/10.1016/j.neo.2018.11.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314220/
https://www.ncbi.nlm.nih.gov/pubmed/30591421
http://dx.doi.org/10.1016/j.neo.2018.11.009

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