Lysosomal oxidation of LDL alters lysosomal pH, induces senescence, and increases secretion of pro-inflammatory cytokines in human macrophages

We have shown that aggregated LDL is internalized by macrophages and oxidized in lysosomes by redox-active iron. We have now investigated to determine whether the lysosomal oxidation of LDL impairs lysosomal function and whether a lysosomotropic antioxidant can prevent these alterations. LDL aggrega...

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Detalles Bibliográficos
Autores principales: Ahmad, Feroz, Leake, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314264/
https://www.ncbi.nlm.nih.gov/pubmed/30397186
http://dx.doi.org/10.1194/jlr.M088245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314264/
https://www.ncbi.nlm.nih.gov/pubmed/30397186
http://dx.doi.org/10.1194/jlr.M088245

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