The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

Hypertrophic cardiomyopathy (HCM) is a genetic form of left ventricular hypertrophy, primarily caused by mutations in sarcomere proteins. The cardiac remodeling that occurs as the disease develops can mask the pathogenic impact of the mutation. Here, to discriminate between mutation-induced and dise...

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Detalles Bibliográficos
Autores principales: Piroddi, Nicoletta, Witjas-Paalberends, E. Rosalie, Ferrara, Claudia, Ferrantini, Cecilia, Vitale, Giulia, Scellini, Beatrice, Wijnker, Paul J.M., Sequiera, Vasco, Dooijes, Dennis, dos Remedios, Cristobal, Schlossarek, Saskia, Leung, Man Ching, Messer, Andrew, Ward, Douglas G., Biggeri, Annibale, Tesi, Chiara, Carrier, Lucie, Redwood, Charles S., Marston, Steven B., van der Velden, Jolanda, Poggesi, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314385/
https://www.ncbi.nlm.nih.gov/pubmed/30578328
http://dx.doi.org/10.1085/jgp.201812160

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