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Regulatory light chain phosphorylation augments length-dependent contraction in PTU-treated rats

Force production by actin–myosin cross-bridges in cardiac muscle is regulated by thin-filament proteins and sarcomere length (SL) throughout the heartbeat. Prior work has shown that myosin regulatory light chain (RLC), which binds to the neck of myosin heavy chain, increases cardiac contractility wh...

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Detalles Bibliográficos
Autores principales: Breithaupt, Jason J., Pulcastro, Hannah C., Awinda, Peter O., DeWitt, David C., Tanner, Bertrand C.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314387/
https://www.ncbi.nlm.nih.gov/pubmed/30523115
http://dx.doi.org/10.1085/jgp.201812158