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The interdependence of gene-regulatory elements and the 3D genome

Imaging studies, high-resolution chromatin conformation maps, and genome-wide occupancy data of architectural proteins have revealed that genome topology is tightly intertwined with gene expression. Cross-talk between gene-regulatory elements is often organized within insulated neighborhoods, and re...

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Detalles Bibliográficos
Autores principales: Vermunt, Marit W., Zhang, Di, Blobel, Gerd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314554/
https://www.ncbi.nlm.nih.gov/pubmed/30442643
http://dx.doi.org/10.1083/jcb.201809040
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author Vermunt, Marit W.
Zhang, Di
Blobel, Gerd A.
author_facet Vermunt, Marit W.
Zhang, Di
Blobel, Gerd A.
author_sort Vermunt, Marit W.
collection PubMed
description Imaging studies, high-resolution chromatin conformation maps, and genome-wide occupancy data of architectural proteins have revealed that genome topology is tightly intertwined with gene expression. Cross-talk between gene-regulatory elements is often organized within insulated neighborhoods, and regulatory cues that induce transcriptional changes can reshape chromatin folding patterns and gene positioning within the nucleus. The cause–consequence relationship of genome architecture and gene expression is intricate, and its molecular mechanisms are under intense investigation. Here, we review the interdependency of transcription and genome organization with emphasis on enhancer–promoter contacts in gene regulation.
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spelling pubmed-63145542019-07-07 The interdependence of gene-regulatory elements and the 3D genome Vermunt, Marit W. Zhang, Di Blobel, Gerd A. J Cell Biol Reviews Imaging studies, high-resolution chromatin conformation maps, and genome-wide occupancy data of architectural proteins have revealed that genome topology is tightly intertwined with gene expression. Cross-talk between gene-regulatory elements is often organized within insulated neighborhoods, and regulatory cues that induce transcriptional changes can reshape chromatin folding patterns and gene positioning within the nucleus. The cause–consequence relationship of genome architecture and gene expression is intricate, and its molecular mechanisms are under intense investigation. Here, we review the interdependency of transcription and genome organization with emphasis on enhancer–promoter contacts in gene regulation. Rockefeller University Press 2019-01-07 /pmc/articles/PMC6314554/ /pubmed/30442643 http://dx.doi.org/10.1083/jcb.201809040 Text en © 2018 Vermunt et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Vermunt, Marit W.
Zhang, Di
Blobel, Gerd A.
The interdependence of gene-regulatory elements and the 3D genome
title The interdependence of gene-regulatory elements and the 3D genome
title_full The interdependence of gene-regulatory elements and the 3D genome
title_fullStr The interdependence of gene-regulatory elements and the 3D genome
title_full_unstemmed The interdependence of gene-regulatory elements and the 3D genome
title_short The interdependence of gene-regulatory elements and the 3D genome
title_sort interdependence of gene-regulatory elements and the 3d genome
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314554/
https://www.ncbi.nlm.nih.gov/pubmed/30442643
http://dx.doi.org/10.1083/jcb.201809040
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