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CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice

A perplexing question in neurodegeneration is why different neurons degenerate. The Purkinje cell degeneration (pcd) mouse displays a dramatic phenotype of degeneration of cerebellar Purkinje cells. Loss of CCP1/Nna1 deglutamylation of tubulin accounts for pcd neurodegeneration, but the mechanism is...

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Detalles Bibliográficos
Autores principales:	Gilmore-Hall, Stephen, Kuo, Jennifer, Ward, Jacqueline M., Zahra, Rabaab, Morrison, Richard S., Perkins, Guy, La Spada, Albert R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314562/ https://www.ncbi.nlm.nih.gov/pubmed/30337352 http://dx.doi.org/10.1083/jcb.201709028

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