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Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents
Metallic Zn alloys have recently gained interest as potential candidates for developing platforms of bioresorbable vascular stents (BVS). Previous studies revealed that Mg alloys used for BVS can degrade too early, whereas PLLA materials may fail to provide effective scaffolding properties. Here we...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314592/ https://www.ncbi.nlm.nih.gov/pubmed/30601854 http://dx.doi.org/10.1371/journal.pone.0209111 |
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author | Hehrlein, Christoph Schorch, Björn Kress, Nadia Arab, Amina von zur Mühlen, Constantin Bode, Christoph Epting, Thomas Haberstroh, Jörg Mey, Lilly Schwarzbach, Hans Kinscherf, Ralf Stachniss, Vitus Schiestel, Stefanie Kovacs, Adalbert Fischer, Harald Nennig, Ernst |
author_facet | Hehrlein, Christoph Schorch, Björn Kress, Nadia Arab, Amina von zur Mühlen, Constantin Bode, Christoph Epting, Thomas Haberstroh, Jörg Mey, Lilly Schwarzbach, Hans Kinscherf, Ralf Stachniss, Vitus Schiestel, Stefanie Kovacs, Adalbert Fischer, Harald Nennig, Ernst |
author_sort | Hehrlein, Christoph |
collection | PubMed |
description | Metallic Zn alloys have recently gained interest as potential candidates for developing platforms of bioresorbable vascular stents (BVS). Previous studies revealed that Mg alloys used for BVS can degrade too early, whereas PLLA materials may fail to provide effective scaffolding properties. Here we report on results of a new bioresorbable, metallic stent made from a Zn-Ag alloy studied in a porcine animal model of thrombosis and restenosis. While the tensile strength (MPa) of Zn-3Ag was higher than that of PLLA and resembled Mg’s (WE43), fracture elongation (%) of Zn-3Ag was much greater (18-fold) than the PLLA’s or Mg alloy’s (WE43). Zn-3Ag exposed to HAoSMC culture medium for 30 days revealed degradation elements consisting of Zn, O, N, C, P, and Na at a 6 nm surface depth. Platelet adhesion rates and blood biocompatibility did not differ between Zn-3Ag, PLLA, Mg (WE43), and non-resorbable Nitinol (NiTi) stent materials. Balloon-expandable Zn-3Ag alloy BVS implanted into iliofemoral arteries of 15 juvenile domestic pigs were easily visible fluoroscopically at implantation, and their bioresorption was readily detectable via X-ray over time. Histologically, arteries with Zn-3Ag BVS were completely endothelialized, covered with neointima, and were patent at 1, 3, and 6 months follow-up with no signs of stent thrombosis. Zn-3Ag alloy appears to be a promising material platform for the fabrication of a new generation of bioresorbable vascular stents. |
format | Online Article Text |
id | pubmed-6314592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63145922019-01-11 Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents Hehrlein, Christoph Schorch, Björn Kress, Nadia Arab, Amina von zur Mühlen, Constantin Bode, Christoph Epting, Thomas Haberstroh, Jörg Mey, Lilly Schwarzbach, Hans Kinscherf, Ralf Stachniss, Vitus Schiestel, Stefanie Kovacs, Adalbert Fischer, Harald Nennig, Ernst PLoS One Research Article Metallic Zn alloys have recently gained interest as potential candidates for developing platforms of bioresorbable vascular stents (BVS). Previous studies revealed that Mg alloys used for BVS can degrade too early, whereas PLLA materials may fail to provide effective scaffolding properties. Here we report on results of a new bioresorbable, metallic stent made from a Zn-Ag alloy studied in a porcine animal model of thrombosis and restenosis. While the tensile strength (MPa) of Zn-3Ag was higher than that of PLLA and resembled Mg’s (WE43), fracture elongation (%) of Zn-3Ag was much greater (18-fold) than the PLLA’s or Mg alloy’s (WE43). Zn-3Ag exposed to HAoSMC culture medium for 30 days revealed degradation elements consisting of Zn, O, N, C, P, and Na at a 6 nm surface depth. Platelet adhesion rates and blood biocompatibility did not differ between Zn-3Ag, PLLA, Mg (WE43), and non-resorbable Nitinol (NiTi) stent materials. Balloon-expandable Zn-3Ag alloy BVS implanted into iliofemoral arteries of 15 juvenile domestic pigs were easily visible fluoroscopically at implantation, and their bioresorption was readily detectable via X-ray over time. Histologically, arteries with Zn-3Ag BVS were completely endothelialized, covered with neointima, and were patent at 1, 3, and 6 months follow-up with no signs of stent thrombosis. Zn-3Ag alloy appears to be a promising material platform for the fabrication of a new generation of bioresorbable vascular stents. Public Library of Science 2019-01-02 /pmc/articles/PMC6314592/ /pubmed/30601854 http://dx.doi.org/10.1371/journal.pone.0209111 Text en © 2019 Hehrlein et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hehrlein, Christoph Schorch, Björn Kress, Nadia Arab, Amina von zur Mühlen, Constantin Bode, Christoph Epting, Thomas Haberstroh, Jörg Mey, Lilly Schwarzbach, Hans Kinscherf, Ralf Stachniss, Vitus Schiestel, Stefanie Kovacs, Adalbert Fischer, Harald Nennig, Ernst Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents |
title | Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents |
title_full | Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents |
title_fullStr | Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents |
title_full_unstemmed | Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents |
title_short | Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents |
title_sort | zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314592/ https://www.ncbi.nlm.nih.gov/pubmed/30601854 http://dx.doi.org/10.1371/journal.pone.0209111 |
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