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Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors
BACKGROUND: Despite the experimental evidence that certain dietary compounds lower the risk of radiation-induced damage to the intestine, clinical data are missing and dietary advice to irradiated patients is not evidence-based. MATERIALS AND METHODS: We have previously identified 28 intestinal heal...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314594/ https://www.ncbi.nlm.nih.gov/pubmed/30601820 http://dx.doi.org/10.1371/journal.pone.0208115 |
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author | Hedelin, Maria Skokic, Viktor Wilderäng, Ulrica Ahlin, Rebecca Bull, Cecilia Sjöberg, Fei Dunberger, Gail Bergmark, Karin Stringer, Andrea Steineck, Gunnar |
author_facet | Hedelin, Maria Skokic, Viktor Wilderäng, Ulrica Ahlin, Rebecca Bull, Cecilia Sjöberg, Fei Dunberger, Gail Bergmark, Karin Stringer, Andrea Steineck, Gunnar |
author_sort | Hedelin, Maria |
collection | PubMed |
description | BACKGROUND: Despite the experimental evidence that certain dietary compounds lower the risk of radiation-induced damage to the intestine, clinical data are missing and dietary advice to irradiated patients is not evidence-based. MATERIALS AND METHODS: We have previously identified 28 intestinal health-related symptoms among 623 gynaecological-cancer survivors (three to fifteen years after radiotherapy) and 344 matched population-based controls. The 28 symptoms were grouped into five radiation-induced survivorship syndromes: defecation-urgency syndrome, fecal-leakage syndrome, excessive mucus discharge, excessive gas discharge and blood discharge. The grouping was based on factor scores produced by Exploratory Factor Analysis in combination with the Variable Cutoff Method. Frequency of food intake was measured by a questionnaire. We evaluated the relationship between dietary intake and the intensity of the five syndromes. RESULTS: With the exception of excessive mucus discharge, the intensity of all syndromes declined with increasing intake of citrus fruits. The intensity of defecation-urgency and fecal-leakage syndrome declined with combined intake of vegetables and citrus fruits. The intensity of excessive mucus discharge was increased with increasing intake of gluten. CONCLUSION: In this observational study, we found an association between a high intake of citrus fruits and vegetables and a lower intensity of the studied radiation-induced cancer survivorship syndromes. Our data suggest it may be worthwhile to continue to search for a role of the diet before, during and after radiotherapy to help the cancer survivor restore her or his intestinal health after irradiation. |
format | Online Article Text |
id | pubmed-6314594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63145942019-01-11 Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors Hedelin, Maria Skokic, Viktor Wilderäng, Ulrica Ahlin, Rebecca Bull, Cecilia Sjöberg, Fei Dunberger, Gail Bergmark, Karin Stringer, Andrea Steineck, Gunnar PLoS One Research Article BACKGROUND: Despite the experimental evidence that certain dietary compounds lower the risk of radiation-induced damage to the intestine, clinical data are missing and dietary advice to irradiated patients is not evidence-based. MATERIALS AND METHODS: We have previously identified 28 intestinal health-related symptoms among 623 gynaecological-cancer survivors (three to fifteen years after radiotherapy) and 344 matched population-based controls. The 28 symptoms were grouped into five radiation-induced survivorship syndromes: defecation-urgency syndrome, fecal-leakage syndrome, excessive mucus discharge, excessive gas discharge and blood discharge. The grouping was based on factor scores produced by Exploratory Factor Analysis in combination with the Variable Cutoff Method. Frequency of food intake was measured by a questionnaire. We evaluated the relationship between dietary intake and the intensity of the five syndromes. RESULTS: With the exception of excessive mucus discharge, the intensity of all syndromes declined with increasing intake of citrus fruits. The intensity of defecation-urgency and fecal-leakage syndrome declined with combined intake of vegetables and citrus fruits. The intensity of excessive mucus discharge was increased with increasing intake of gluten. CONCLUSION: In this observational study, we found an association between a high intake of citrus fruits and vegetables and a lower intensity of the studied radiation-induced cancer survivorship syndromes. Our data suggest it may be worthwhile to continue to search for a role of the diet before, during and after radiotherapy to help the cancer survivor restore her or his intestinal health after irradiation. Public Library of Science 2019-01-02 /pmc/articles/PMC6314594/ /pubmed/30601820 http://dx.doi.org/10.1371/journal.pone.0208115 Text en © 2019 Hedelin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hedelin, Maria Skokic, Viktor Wilderäng, Ulrica Ahlin, Rebecca Bull, Cecilia Sjöberg, Fei Dunberger, Gail Bergmark, Karin Stringer, Andrea Steineck, Gunnar Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors |
title | Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors |
title_full | Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors |
title_fullStr | Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors |
title_full_unstemmed | Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors |
title_short | Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors |
title_sort | intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314594/ https://www.ncbi.nlm.nih.gov/pubmed/30601820 http://dx.doi.org/10.1371/journal.pone.0208115 |
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