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Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study

BACKGROUND: Older emergency department (ED) patients are at risk for adverse outcomes, however, it is hard to predict these. We aimed to assess the discriminatory value of clinical intuition, operationalized as disease perception, self-rated health and first clinical impression, including the 30-day...

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Autores principales: Zelis, Noortje, Mauritz, Arisja N., Kuijpers, Lonne I. J., Buijs, Jacqueline, de Leeuw, Peter W., Stassen, Patricia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314634/
https://www.ncbi.nlm.nih.gov/pubmed/30601815
http://dx.doi.org/10.1371/journal.pone.0208741
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author Zelis, Noortje
Mauritz, Arisja N.
Kuijpers, Lonne I. J.
Buijs, Jacqueline
de Leeuw, Peter W.
Stassen, Patricia M.
author_facet Zelis, Noortje
Mauritz, Arisja N.
Kuijpers, Lonne I. J.
Buijs, Jacqueline
de Leeuw, Peter W.
Stassen, Patricia M.
author_sort Zelis, Noortje
collection PubMed
description BACKGROUND: Older emergency department (ED) patients are at risk for adverse outcomes, however, it is hard to predict these. We aimed to assess the discriminatory value of clinical intuition, operationalized as disease perception, self-rated health and first clinical impression, including the 30-day surprise question (SQ: “Would I be surprised if this patient died in the next 30 days” of patients, nurses and physicians. Endpoints used to evaluate the discriminatory value of clinical intuition were short-term (30-day) mortality and other adverse outcomes (intensive/medium care admission, prolonged length of hospital stay, loss of independent living or 30-day readmission). METHODS: In this prospective, multicentre cohort study, older medical patients (≥65 years), nurses and physicians filled in scores regarding severity of illness and their concerns (i.e. disease perception and clinical impression scores) immediately after arrival of the patient in the ED. In addition, patients filled in a self-rated health score and nurses and physicians answered the SQ. Area under the curves (AUCs) of receiver operating characteristics (ROCs) were calculated. RESULTS: The median age of the 602 included patients was 79 years and 86.7% were community dwelling. Within 30 days, 66 (11.0%) patients died and 263 (43.7%) patients met the composite endpoint. The severity of concern score of both nurses and physicians yielded the highest AUCs for 30-day mortality (for both 0.75; 95%CI 0.68–0.81). AUCs for the severity of illness score and SQ of nurses and physicians ranged from 0.71 to 0.74 while those for the disease perception and self-rated health of patients ranged from 0.64 to 0.69. The discriminatory value of the scores for the composite endpoint was lower (AUCs ranging from 0.60 to 0.67). We used scores that have not been previously validated which could influence their generalisability. CONCLUSION: Clinical intuition,—disease perception, self-rated health and first clinical impression—documented at an early stage after arrival in the ED, is a useful clinical tool to predict mortality and other adverse outcomes in older ED patients. Highest discriminatory values were found for the nurses’ and physicians’ severity of concern score. Intuition may be helpful for the implementation of personalised medical care in the future.
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spelling pubmed-63146342019-01-11 Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study Zelis, Noortje Mauritz, Arisja N. Kuijpers, Lonne I. J. Buijs, Jacqueline de Leeuw, Peter W. Stassen, Patricia M. PLoS One Research Article BACKGROUND: Older emergency department (ED) patients are at risk for adverse outcomes, however, it is hard to predict these. We aimed to assess the discriminatory value of clinical intuition, operationalized as disease perception, self-rated health and first clinical impression, including the 30-day surprise question (SQ: “Would I be surprised if this patient died in the next 30 days” of patients, nurses and physicians. Endpoints used to evaluate the discriminatory value of clinical intuition were short-term (30-day) mortality and other adverse outcomes (intensive/medium care admission, prolonged length of hospital stay, loss of independent living or 30-day readmission). METHODS: In this prospective, multicentre cohort study, older medical patients (≥65 years), nurses and physicians filled in scores regarding severity of illness and their concerns (i.e. disease perception and clinical impression scores) immediately after arrival of the patient in the ED. In addition, patients filled in a self-rated health score and nurses and physicians answered the SQ. Area under the curves (AUCs) of receiver operating characteristics (ROCs) were calculated. RESULTS: The median age of the 602 included patients was 79 years and 86.7% were community dwelling. Within 30 days, 66 (11.0%) patients died and 263 (43.7%) patients met the composite endpoint. The severity of concern score of both nurses and physicians yielded the highest AUCs for 30-day mortality (for both 0.75; 95%CI 0.68–0.81). AUCs for the severity of illness score and SQ of nurses and physicians ranged from 0.71 to 0.74 while those for the disease perception and self-rated health of patients ranged from 0.64 to 0.69. The discriminatory value of the scores for the composite endpoint was lower (AUCs ranging from 0.60 to 0.67). We used scores that have not been previously validated which could influence their generalisability. CONCLUSION: Clinical intuition,—disease perception, self-rated health and first clinical impression—documented at an early stage after arrival in the ED, is a useful clinical tool to predict mortality and other adverse outcomes in older ED patients. Highest discriminatory values were found for the nurses’ and physicians’ severity of concern score. Intuition may be helpful for the implementation of personalised medical care in the future. Public Library of Science 2019-01-02 /pmc/articles/PMC6314634/ /pubmed/30601815 http://dx.doi.org/10.1371/journal.pone.0208741 Text en © 2019 Zelis et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zelis, Noortje
Mauritz, Arisja N.
Kuijpers, Lonne I. J.
Buijs, Jacqueline
de Leeuw, Peter W.
Stassen, Patricia M.
Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study
title Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study
title_full Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study
title_fullStr Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study
title_full_unstemmed Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study
title_short Short-term mortality in older medical emergency patients can be predicted using clinical intuition: A prospective study
title_sort short-term mortality in older medical emergency patients can be predicted using clinical intuition: a prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314634/
https://www.ncbi.nlm.nih.gov/pubmed/30601815
http://dx.doi.org/10.1371/journal.pone.0208741
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