Cargando…

Genetic and structural insights into broad neutralization of hepatitis C virus by human V(H)1-69 antibodies

An effective vaccine to the antigenically diverse hepatitis C virus (HCV) must target conserved immune epitopes. Here, we investigate cross-neutralization of HCV genotypes by broadly neutralizing antibodies (bNAbs) encoded by the relatively abundant human gene family V(H)1-69. We have deciphered the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tzarum, Netanel, Giang, Erick, Kong, Leopold, He, Linling, Prentoe, Jannick, Augestad, Elias, Hua, Yuanzi, Castillo, Shaun, Lauer, Georg M., Bukh, Jens, Zhu, Jiang, Wilson, Ian A., Law, Mansun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314831/ https://www.ncbi.nlm.nih.gov/pubmed/30613781 http://dx.doi.org/10.1126/sciadv.aav1882

Ejemplares similares

An alternate conformation of HCV E2 neutralizing face as an additional vaccine target
por: Tzarum, Netanel, et al.
Publicado: (2020)

Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A
por: Velázquez-Moctezuma, Rodrigo, et al.
Publicado: (2017)

The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein
por: Tzarum, Netanel, et al.
Publicado: (2018)

Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
por: Prentoe, Jannick, et al.
Publicado: (2018)

Identification of novel neutralizing determinants for protection against HCV
por: Alzua, Garazi P., et al.
Publicado: (2023)

In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus
por: Olesen, Christina Holmboe, et al.
Publicado: (2021)

Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity
por: Augestad, Elias H., et al.
Publicado: (2020)

From Structural Studies to HCV Vaccine Design
por: Yechezkel, Itai, et al.
Publicado: (2021)

Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines
por: He, Linling, et al.
Publicado: (2020)

Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice
por: Alzua, Garazi Pena, et al.
Publicado: (2023)

Mechanisms of Hepatitis C Virus Escape from Vaccine-Relevant Neutralizing Antibodies
por: Velázquez-Moctezuma, Rodrigo, et al.
Publicado: (2021)

Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis
por: Gopal, Radhika, et al.
Publicado: (2017)

Specific Antibodies Induced by Immunization with Hepatitis B Virus-Like Particles Carrying Hepatitis C Virus Envelope Glycoprotein 2 Epitopes Show Differential Neutralization Efficiency
por: Czarnota, Anna, et al.
Publicado: (2020)

Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization
por: Pham, Long V., et al.
Publicado: (2022)

Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens
por: Prentoe, Jannick, et al.
Publicado: (2021)

Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding
por: He, Linling, et al.
Publicado: (2015)

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design
por: Keck, Zhen-Yong, et al.
Publicado: (2019)

Analysis of Functional Differences between Hepatitis C Virus NS5A of Genotypes 1–7 in Infectious Cell Culture Systems
por: Scheel, Troels K. H., et al.
Publicado: (2012)

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice
por: Prentoe, Jannick, et al.
Publicado: (2016)

High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals
por: Pihl, Anne F., et al.
Publicado: (2018)

Stringent and complex sequence constraints of an IGHV1–69 broadly neutralizing antibody to influenza HA stem
por: Teo, Qi Wen, et al.
Publicado: (2023)

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate
por: Keck, Zhen-yong, et al.
Publicado: (2012)

Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers
por: Morris, Charles D., et al.
Publicado: (2017)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
por: Prentoe, Jannick, et al.
Publicado: (2022)

A polyvalent coral snake antivenom with broad neutralization capacity
por: Castillo-Beltrán, María Carlina, et al.
Publicado: (2019)

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
por: Sok, Devin, et al.
Publicado: (2017)

A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans
por: Law, John Lok Man, et al.
Publicado: (2013)

Broadly Neutralizing Antibodies for HIV Eradication
por: Stephenson, Kathryn E., et al.
Publicado: (2016)

Tackling influenza with broadly neutralizing antibodies
por: Corti, Davide, et al.
Publicado: (2017)

Structural basis for broad coronavirus neutralization
por: Sauer, Maximilian M., et al.
Publicado: (2021)

Broadly Neutralizing Synthetic Cannabinoid Vaccines
por: Lin, Mingliang, et al.
Publicado: (2020)

Antibodies against viruses: passive and active immunization
por: Law, Mansun, et al.
Publicado: (2008)

Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
por: Pinto, Dora, et al.
Publicado: (2019)

Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope
por: Anthony, Colin, et al.
Publicado: (2017)

Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
por: Landais, Elise, et al.
Publicado: (2018)

Dionysus in 69 /
Publicado: (1970)

HIV vaccine development and broadly neutralizing antibodies
por: Greenspan, Neil S., et al.
Publicado: (2015)

The expanding array of HIV broadly neutralizing antibodies
por: McCoy, Laura E.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nfl7jnf2jmnf7ugn890gf6i9df