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Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice
Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the role of NPR-C in angiotensin II (Ang II)-mediated SAN...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314975/ https://www.ncbi.nlm.nih.gov/pubmed/30623142 http://dx.doi.org/10.1016/j.jacbts.2018.08.004 |
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author | Mackasey, Martin Egom, Emmanuel E. Jansen, Hailey J. Hua, Rui Moghtadaei, Motahareh Liu, Yingjie Kaur, Jaspreet McRae, Megan D. Bogachev, Oleg Rafferty, Sara A. Ray, Gibanananda Kirkby, Adam W. Rose, Robert A. |
author_facet | Mackasey, Martin Egom, Emmanuel E. Jansen, Hailey J. Hua, Rui Moghtadaei, Motahareh Liu, Yingjie Kaur, Jaspreet McRae, Megan D. Bogachev, Oleg Rafferty, Sara A. Ray, Gibanananda Kirkby, Adam W. Rose, Robert A. |
author_sort | Mackasey, Martin |
collection | PubMed |
description | Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the role of NPR-C in angiotensin II (Ang II)-mediated SAN disease in mice. Ang II caused SAN disease due to impaired electrical activity in SAN myocytes and increased SAN fibrosis. Strikingly, Ang II treatment in NPR-C(−/−) mice worsened SAN disease, whereas co-treatment of wild-type mice with Ang II and a selective NPR-C agonist (cANF) prevented SAN dysfunction. NPR-C may represent a new target to protect against the development of Ang II-induced SAN disease. |
format | Online Article Text |
id | pubmed-6314975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63149752019-01-08 Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice Mackasey, Martin Egom, Emmanuel E. Jansen, Hailey J. Hua, Rui Moghtadaei, Motahareh Liu, Yingjie Kaur, Jaspreet McRae, Megan D. Bogachev, Oleg Rafferty, Sara A. Ray, Gibanananda Kirkby, Adam W. Rose, Robert A. JACC Basic Transl Sci PRECLINICAL RESEARCH Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated the role of NPR-C in angiotensin II (Ang II)-mediated SAN disease in mice. Ang II caused SAN disease due to impaired electrical activity in SAN myocytes and increased SAN fibrosis. Strikingly, Ang II treatment in NPR-C(−/−) mice worsened SAN disease, whereas co-treatment of wild-type mice with Ang II and a selective NPR-C agonist (cANF) prevented SAN dysfunction. NPR-C may represent a new target to protect against the development of Ang II-induced SAN disease. Elsevier 2018-12-05 /pmc/articles/PMC6314975/ /pubmed/30623142 http://dx.doi.org/10.1016/j.jacbts.2018.08.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | PRECLINICAL RESEARCH Mackasey, Martin Egom, Emmanuel E. Jansen, Hailey J. Hua, Rui Moghtadaei, Motahareh Liu, Yingjie Kaur, Jaspreet McRae, Megan D. Bogachev, Oleg Rafferty, Sara A. Ray, Gibanananda Kirkby, Adam W. Rose, Robert A. Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice |
title | Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice |
title_full | Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice |
title_fullStr | Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice |
title_full_unstemmed | Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice |
title_short | Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice |
title_sort | natriuretic peptide receptor-c protects against angiotensin ii-mediated sinoatrial node disease in mice |
topic | PRECLINICAL RESEARCH |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314975/ https://www.ncbi.nlm.nih.gov/pubmed/30623142 http://dx.doi.org/10.1016/j.jacbts.2018.08.004 |
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