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∆(9)-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB(1) receptor

PURPOSE: ∆(9)-Tetrahydrocannabinol (∆(9)-THC) and cannabidiol (CBD), major psychoactive constituents of marijuana, induce potentiation of pentobarbital-induced sleep in mice. We have elucidated the mechanism of enhancement of the anesthetic effect of pentobarbital by cannabinoids. METHODS: We carrie...

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Detalles Bibliográficos
Autores principales:	Kimura, Toshiyuki, Takaya, Makiko, Usami, Noriyuki, Watanabe, Kazuhito, Yamamoto, Ikuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Japan 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314990/ https://www.ncbi.nlm.nih.gov/pubmed/30636988 http://dx.doi.org/10.1007/s11419-018-0457-2

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