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Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

Bone is one of the preferred sites for the metastasis of malignant tumours, such as breast cancer, lung cancer and malignant melanoma. Tumour cells colonizing bone have the capacity to induce the expression of receptor activator of nuclear factor-κB ligand (RANKL), which promotes osteoclast differen...

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Detalles Bibliográficos
Autores principales:	Nakai, Yuta, Okamoto, Kazuo, Terashima, Asuka, Ehata, Shogo, Nishida, Jun, Imamura, Takeshi, Ono, Takashi, Takayanagi, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315020/ https://www.ncbi.nlm.nih.gov/pubmed/30622830 http://dx.doi.org/10.1038/s41413-018-0036-5

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