Pharmacological stimulation of NQO1 decreases NADPH levels and ameliorates acute pancreatitis in mice

Reactive oxygen species (ROS) regulates the activation of inflammatory cascades and tissue damage in acute pancreatitis. NADPH oxidase (NOX) is upregulated in pancreatitis and is one of the major enzymes involved in ROS production using NADPH as a general rate-limiting substrate. Dunnione, a well-kn...

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Detalles Bibliográficos
Autores principales: Shen, AiHua, Kim, Hyung-Jin, Oh, Gi-Su, Lee, Su-Bin, Lee, SeungHoon, Pandit, Arpana, Khadka, Dipendra, Sharma, Subham, Kim, Seon Young, Choe, Seong-Kyu, Yang, Sei-Hoon, Cho, Eun-Young, Shim, Hyuk, Park, Raekil, Kwak, Tae Hwan, So, Hong-Seob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315021/
https://www.ncbi.nlm.nih.gov/pubmed/30584237
http://dx.doi.org/10.1038/s41419-018-1252-z

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