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Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration

There is a well-established link between cytokine expression and the progression of intervertebral disc degeneration. Among these cytokines, interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are the most commonly studied. To investigate whether systemic hTNF-α overexpression affects interve...

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Detalles Bibliográficos
Autores principales:	Gorth, Deborah J., Shapiro, Irving M., Risbud, Makarand V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315044/ https://www.ncbi.nlm.nih.gov/pubmed/30584238 http://dx.doi.org/10.1038/s41419-018-1246-x

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