Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure

Cardioprotective effects of H(2)S have been well documented. However, the lack of evidence supporting the benefits afforded by delayed H(2)S therapy warrants further investigation. Using a murine model of transverse aortic constriction-induced heart failure, this study showed that delayed H(2)S therapy protects multiple organs including the heart, kidney, and blood-vessel; reduces oxidative stress; attenuates renal sympathetic and renin-angiotensin-aldosterone system pathological activation; and ultimately improves exercise capacity. These findings provide further insights into H(2)S-mediated cardiovascular protection and implicate the benefits of using H(2)S-based therapies clinically for the treatment of heart failure.