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Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus
BACKGROUND: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. CASE REPORT: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Columbia University Libraries/Information Services
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315060/ https://www.ncbi.nlm.nih.gov/pubmed/30622836 http://dx.doi.org/10.7916/D8NK4XVP |
Sumario: | BACKGROUND: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. CASE REPORT: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD. DISCUSSION: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents. |
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