Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus

BACKGROUND: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. CASE REPORT: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These s...

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Autores principales: Manzke, Pedro, Grippe, Talyta, Tavares, Georgia L., Leal, Lucas C., Roze, Emmanuel, Apartis, Emmanuelle, Maciel Dias, Ronaldo, Ferreira, André G. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315060/
https://www.ncbi.nlm.nih.gov/pubmed/30622836
http://dx.doi.org/10.7916/D8NK4XVP
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author Manzke, Pedro
Grippe, Talyta
Tavares, Georgia L.
Leal, Lucas C.
Roze, Emmanuel
Apartis, Emmanuelle
Maciel Dias, Ronaldo
Ferreira, André G. F.
author_facet Manzke, Pedro
Grippe, Talyta
Tavares, Georgia L.
Leal, Lucas C.
Roze, Emmanuel
Apartis, Emmanuelle
Maciel Dias, Ronaldo
Ferreira, André G. F.
author_sort Manzke, Pedro
collection PubMed
description BACKGROUND: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. CASE REPORT: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD. DISCUSSION: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.
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spelling pubmed-63150602019-01-08 Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus Manzke, Pedro Grippe, Talyta Tavares, Georgia L. Leal, Lucas C. Roze, Emmanuel Apartis, Emmanuelle Maciel Dias, Ronaldo Ferreira, André G. F. Tremor Other Hyperkinet Mov (N Y) Case Reports BACKGROUND: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. CASE REPORT: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD. DISCUSSION: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents. Columbia University Libraries/Information Services 2018-11-01 /pmc/articles/PMC6315060/ /pubmed/30622836 http://dx.doi.org/10.7916/D8NK4XVP Text en © 2018 Termsarasab et al. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
spellingShingle Case Reports
Manzke, Pedro
Grippe, Talyta
Tavares, Georgia L.
Leal, Lucas C.
Roze, Emmanuel
Apartis, Emmanuelle
Maciel Dias, Ronaldo
Ferreira, André G. F.
Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus
title Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus
title_full Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus
title_fullStr Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus
title_full_unstemmed Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus
title_short Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus
title_sort anti-gad antibody-associated syndrome presenting with limb myoclonus
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315060/
https://www.ncbi.nlm.nih.gov/pubmed/30622836
http://dx.doi.org/10.7916/D8NK4XVP
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