Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells

The SRC-family kinase LYN is highly expressed in triple-negative/basal-like breast cancer (TNBC) and in the cell of origin of these tumors, c-KIT-positive luminal progenitors. Here, we demonstrate LYN is a downstream effector of c-KIT in normal mammary cells and protective of apoptosis upon genotoxi...

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Detalles Bibliográficos
Autores principales: Tornillo, Giusy, Knowlson, Catherine, Kendrick, Howard, Cooke, Joe, Mirza, Hasan, Aurrekoetxea-Rodríguez, Iskander, Vivanco, Maria d.M., Buckley, Niamh E., Grigoriadis, Anita, Smalley, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315108/
https://www.ncbi.nlm.nih.gov/pubmed/30590041
http://dx.doi.org/10.1016/j.celrep.2018.11.103

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