Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer

The exact identity of castrate-resistant (CR) cells and their relation to CR prostate cancer (CRPC) is unresolved. We use single-cell gene profiling to analyze the molecular heterogeneity in basal and luminal compartments. Within the luminal compartment, we identify a subset of cells intrinsically r...

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Detalles Bibliográficos
Autores principales: Barros-Silva, João D., Linn, Douglas E., Steiner, Ivana, Guo, Guoji, Ali, Adnan, Pakula, Hubert, Ashton, Garry, Peset, Isabel, Brown, Michael, Clarke, Noel W., Bronson, Roderick T., Yuan, Guo-Cheng, Orkin, Stuart H., Li, Zhe, Baena, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315111/
https://www.ncbi.nlm.nih.gov/pubmed/30566873
http://dx.doi.org/10.1016/j.celrep.2018.11.069

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