Cargando…
More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking
Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature. Consequently, scavenger receptors are known to play important roles...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315190/ https://www.ncbi.nlm.nih.gov/pubmed/30631321 http://dx.doi.org/10.3389/fimmu.2018.02904 |
_version_ | 1783384234751164416 |
---|---|
author | Patten, Daniel A. Shetty, Shishir |
author_facet | Patten, Daniel A. Shetty, Shishir |
author_sort | Patten, Daniel A. |
collection | PubMed |
description | Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature. Consequently, scavenger receptors are known to play important roles in host homeostasis, with common endogenous ligands including apoptotic cells, and modified low density lipoproteins (LDLs); additionally, scavenger receptors are key regulators of inflammatory diseases, such as atherosclerosis. Also, as a consequence of their affinity for a wide range of microbial products, their role in innate immunity is also being increasingly studied. However, in this review, a secondary function of a number of endothelial-expressed scavenger receptors is discussed. There is increasing evidence that some endothelial-expressed scavenger receptors are able to directly bind leukocyte-expressed ligands and subsequently act as adhesion molecules in the trafficking of leukocytes in lymphatic and vascular tissues. Here, we cover the current literature on this alternative role for endothelial-expressed scavenger receptors and also speculate on their therapeutic potential. |
format | Online Article Text |
id | pubmed-6315190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63151902019-01-10 More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking Patten, Daniel A. Shetty, Shishir Front Immunol Immunology Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature. Consequently, scavenger receptors are known to play important roles in host homeostasis, with common endogenous ligands including apoptotic cells, and modified low density lipoproteins (LDLs); additionally, scavenger receptors are key regulators of inflammatory diseases, such as atherosclerosis. Also, as a consequence of their affinity for a wide range of microbial products, their role in innate immunity is also being increasingly studied. However, in this review, a secondary function of a number of endothelial-expressed scavenger receptors is discussed. There is increasing evidence that some endothelial-expressed scavenger receptors are able to directly bind leukocyte-expressed ligands and subsequently act as adhesion molecules in the trafficking of leukocytes in lymphatic and vascular tissues. Here, we cover the current literature on this alternative role for endothelial-expressed scavenger receptors and also speculate on their therapeutic potential. Frontiers Media S.A. 2018-12-12 /pmc/articles/PMC6315190/ /pubmed/30631321 http://dx.doi.org/10.3389/fimmu.2018.02904 Text en Copyright © 2018 Patten and Shetty. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Patten, Daniel A. Shetty, Shishir More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking |
title | More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking |
title_full | More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking |
title_fullStr | More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking |
title_full_unstemmed | More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking |
title_short | More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking |
title_sort | more than just a removal service: scavenger receptors in leukocyte trafficking |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315190/ https://www.ncbi.nlm.nih.gov/pubmed/30631321 http://dx.doi.org/10.3389/fimmu.2018.02904 |
work_keys_str_mv | AT pattendaniela morethanjustaremovalservicescavengerreceptorsinleukocytetrafficking AT shettyshishir morethanjustaremovalservicescavengerreceptorsinleukocytetrafficking |