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Proteasome Inhibitor-Induced IκB/NF-κB Activation is Mediated by Nrf2-Dependent Light Chain 3B Induction in Lung Cancer Cells

IκB, a cytoplasmic inhibitor of nuclear factor-κB (NF-κB), is reportedly degraded via the proteasome. However, we recently found that long-term incubation with proteasome inhibitors (PIs) such as PS-341 or MG132 induces IκBα degradation via an alternative pathway, lysosome, which results in NF-κB ac...

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Detalles Bibliográficos
Autores principales:	Lee, Kyoung-Hee, Lee, Jungsil, Woo, Jisu, Lee, Chang-Hoon, Yoo, Chul-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315323/ https://www.ncbi.nlm.nih.gov/pubmed/30396235 http://dx.doi.org/10.14348/molcells.2018.0277

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