First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal

Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and viru...

Descripción completa

Detalles Bibliográficos
Autores principales: Caneiras, Cátia, Calisto, Filipa, Jorge da Silva, Gabriela, Lito, Luis, Melo-Cristino, José, Duarte, Aida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315367/
https://www.ncbi.nlm.nih.gov/pubmed/30404152
http://dx.doi.org/10.3390/antibiotics7040096
_version_ 1783384277501607936
author Caneiras, Cátia
Calisto, Filipa
Jorge da Silva, Gabriela
Lito, Luis
Melo-Cristino, José
Duarte, Aida
author_facet Caneiras, Cátia
Calisto, Filipa
Jorge da Silva, Gabriela
Lito, Luis
Melo-Cristino, José
Duarte, Aida
author_sort Caneiras, Cátia
collection PubMed
description Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes bla(KPC-3), bla(TEM-1) and bla(SHV-1) in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.
format Online
Article
Text
id pubmed-6315367
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63153672019-01-11 First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal Caneiras, Cátia Calisto, Filipa Jorge da Silva, Gabriela Lito, Luis Melo-Cristino, José Duarte, Aida Antibiotics (Basel) Case Report Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes bla(KPC-3), bla(TEM-1) and bla(SHV-1) in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin. MDPI 2018-11-06 /pmc/articles/PMC6315367/ /pubmed/30404152 http://dx.doi.org/10.3390/antibiotics7040096 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Caneiras, Cátia
Calisto, Filipa
Jorge da Silva, Gabriela
Lito, Luis
Melo-Cristino, José
Duarte, Aida
First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal
title First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal
title_full First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal
title_fullStr First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal
title_full_unstemmed First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal
title_short First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal
title_sort first description of colistin and tigecycline-resistant acinetobacter baumannii producing kpc-3 carbapenemase in portugal
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315367/
https://www.ncbi.nlm.nih.gov/pubmed/30404152
http://dx.doi.org/10.3390/antibiotics7040096
work_keys_str_mv AT caneirascatia firstdescriptionofcolistinandtigecyclineresistantacinetobacterbaumanniiproducingkpc3carbapenemaseinportugal
AT calistofilipa firstdescriptionofcolistinandtigecyclineresistantacinetobacterbaumanniiproducingkpc3carbapenemaseinportugal
AT jorgedasilvagabriela firstdescriptionofcolistinandtigecyclineresistantacinetobacterbaumanniiproducingkpc3carbapenemaseinportugal
AT litoluis firstdescriptionofcolistinandtigecyclineresistantacinetobacterbaumanniiproducingkpc3carbapenemaseinportugal
AT melocristinojose firstdescriptionofcolistinandtigecyclineresistantacinetobacterbaumanniiproducingkpc3carbapenemaseinportugal
AT duarteaida firstdescriptionofcolistinandtigecyclineresistantacinetobacterbaumanniiproducingkpc3carbapenemaseinportugal

Ejemplares similares