Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish

Patients with inherited dilated cardiomyopathy (DCM) often suffer from severe heart failure based on impaired cardiac contractility leading to increased morbidity and mortality. Integrin-linked kinase (ILK) as a part of the cardiac mechanical stretch sensor was found to be an essential genetic regul...

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Detalles Bibliográficos
Autores principales: Pott, Alexander, Shahid, Maryam, Köhler, Doreen, Pylatiuk, Christian, Weinmann, Karolina, Just, Steffen, Rottbauer, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315389/
https://www.ncbi.nlm.nih.gov/pubmed/30463267
http://dx.doi.org/10.3390/biom8040153

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