A Divergent Hepatitis D-Like Agent in Birds

Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secon...

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Autores principales: Wille, Michelle, Netter, Hans J., Littlejohn, Margaret, Yuen, Lilly, Shi, Mang, Eden, John-Sebastian, Klaassen, Marcel, Holmes, Edward C., Hurt, Aeron C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315422/
https://www.ncbi.nlm.nih.gov/pubmed/30562970
http://dx.doi.org/10.3390/v10120720
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author Wille, Michelle
Netter, Hans J.
Littlejohn, Margaret
Yuen, Lilly
Shi, Mang
Eden, John-Sebastian
Klaassen, Marcel
Holmes, Edward C.
Hurt, Aeron C.
author_facet Wille, Michelle
Netter, Hans J.
Littlejohn, Margaret
Yuen, Lilly
Shi, Mang
Eden, John-Sebastian
Klaassen, Marcel
Holmes, Edward C.
Hurt, Aeron C.
author_sort Wille, Michelle
collection PubMed
description Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents.
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spelling pubmed-63154222019-01-10 A Divergent Hepatitis D-Like Agent in Birds Wille, Michelle Netter, Hans J. Littlejohn, Margaret Yuen, Lilly Shi, Mang Eden, John-Sebastian Klaassen, Marcel Holmes, Edward C. Hurt, Aeron C. Viruses Article Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents. MDPI 2018-12-17 /pmc/articles/PMC6315422/ /pubmed/30562970 http://dx.doi.org/10.3390/v10120720 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wille, Michelle
Netter, Hans J.
Littlejohn, Margaret
Yuen, Lilly
Shi, Mang
Eden, John-Sebastian
Klaassen, Marcel
Holmes, Edward C.
Hurt, Aeron C.
A Divergent Hepatitis D-Like Agent in Birds
title A Divergent Hepatitis D-Like Agent in Birds
title_full A Divergent Hepatitis D-Like Agent in Birds
title_fullStr A Divergent Hepatitis D-Like Agent in Birds
title_full_unstemmed A Divergent Hepatitis D-Like Agent in Birds
title_short A Divergent Hepatitis D-Like Agent in Birds
title_sort divergent hepatitis d-like agent in birds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315422/
https://www.ncbi.nlm.nih.gov/pubmed/30562970
http://dx.doi.org/10.3390/v10120720
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