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Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females

Polymorphisms of the estrogen receptor ESR1 and ESR2 genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the ESR1 and ESR2 ge...

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Autores principales: Gutiérrez-Muñoz, Mayra, Fajardo-Araujo, Martha E., González-Pérez, Erika G., Aguirre-Arzola, Victor E., Solís-Ortiz, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315436/
https://www.ncbi.nlm.nih.gov/pubmed/30544539
http://dx.doi.org/10.3390/brainsci8120219
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author Gutiérrez-Muñoz, Mayra
Fajardo-Araujo, Martha E.
González-Pérez, Erika G.
Aguirre-Arzola, Victor E.
Solís-Ortiz, Silvia
author_facet Gutiérrez-Muñoz, Mayra
Fajardo-Araujo, Martha E.
González-Pérez, Erika G.
Aguirre-Arzola, Victor E.
Solís-Ortiz, Silvia
author_sort Gutiérrez-Muñoz, Mayra
collection PubMed
description Polymorphisms of the estrogen receptor ESR1 and ESR2 genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the ESR1 and ESR2 genes on the responses to the facial emotion recognition task in females. Postmenopausal healthy female volunteers were genotyped for the polymorphisms Xbal and PvuII of ESR1 and the polymorphism rs1256030 of ESR2. The effect of these polymorphisms on the response to the facial emotion recognition of the emotions happiness, sadness, disgust, anger, surprise, and fear was analyzed. Females carrying the P allele of the PvuII polymorphism or the X allele of the Xbal polymorphism of ESR1 easily recognized facial expressions of sadness that were more difficult for the women carrying the p allele or the x allele. They displayed higher accuracy, fast response time, more correct responses, and fewer omissions to complete the task, with a large effect size. Women carrying the ESR2 C allele of ESR2 showed a faster response time for recognizing facial expressions of anger. These findings link ESR1 and ESR2 polymorphisms in facial emotion recognition of negative emotions.
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spelling pubmed-63154362019-01-11 Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females Gutiérrez-Muñoz, Mayra Fajardo-Araujo, Martha E. González-Pérez, Erika G. Aguirre-Arzola, Victor E. Solís-Ortiz, Silvia Brain Sci Article Polymorphisms of the estrogen receptor ESR1 and ESR2 genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the ESR1 and ESR2 genes on the responses to the facial emotion recognition task in females. Postmenopausal healthy female volunteers were genotyped for the polymorphisms Xbal and PvuII of ESR1 and the polymorphism rs1256030 of ESR2. The effect of these polymorphisms on the response to the facial emotion recognition of the emotions happiness, sadness, disgust, anger, surprise, and fear was analyzed. Females carrying the P allele of the PvuII polymorphism or the X allele of the Xbal polymorphism of ESR1 easily recognized facial expressions of sadness that were more difficult for the women carrying the p allele or the x allele. They displayed higher accuracy, fast response time, more correct responses, and fewer omissions to complete the task, with a large effect size. Women carrying the ESR2 C allele of ESR2 showed a faster response time for recognizing facial expressions of anger. These findings link ESR1 and ESR2 polymorphisms in facial emotion recognition of negative emotions. MDPI 2018-12-07 /pmc/articles/PMC6315436/ /pubmed/30544539 http://dx.doi.org/10.3390/brainsci8120219 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gutiérrez-Muñoz, Mayra
Fajardo-Araujo, Martha E.
González-Pérez, Erika G.
Aguirre-Arzola, Victor E.
Solís-Ortiz, Silvia
Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females
title Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females
title_full Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females
title_fullStr Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females
title_full_unstemmed Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females
title_short Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females
title_sort facial sadness recognition is modulated by estrogen receptor gene polymorphisms in healthy females
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315436/
https://www.ncbi.nlm.nih.gov/pubmed/30544539
http://dx.doi.org/10.3390/brainsci8120219
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